Literature DB >> 15528406

Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel.

Sandile E J Williams1, Phillippa Wootton, Helen S Mason, Jonathan Bould, David E Iles, Daniela Riccardi, Chris Peers, Paul J Kemp.   

Abstract

Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia. Knockdown of HO-2 expression reduced channel activity, and carbon monoxide, a product of HO-2 activity, rescued this loss of function. Inhibition of BK channels by hypoxia was dependent on HO-2 expression and was augmented by HO-2 stimulation. Furthermore, carotid body cells demonstrated HO-2-dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation.

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Year:  2004        PMID： 15528406     DOI： 10.1126/science.1105010

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  147 in total

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Review 9.  Sensing hypoxia: physiology, genetics and epigenetics.

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