A clinical application of an automated phantom-film QA procedure for validation of IMRT treatment planning and delivery.

To quantify the correlation between planned and delivered intensity-modulated radiation therapy (IMRT) dose distributions, IMRT plans for 37 prostate carcinoma patients were analyzed. IMRT treatment plans were converted into hybrid phantom plans using a commercially available treatment planning system and delivered to a specialized film phantom via a static-tomotherapy technique. The films were analyzed using a commercial film dosimetry system. Hybrid phantom axial dose maps and film images were normalized, registered to one another, and subtracted to calculate the overall relative dose difference throughout the entire film area on a pixel-by-pixel basis. The average percentage of pixels with dose-difference values greater than +/- 3% among analyzed hybrid patient plans was 8.6% +/- 3%. The average percentage of pixels with dose differences greater than +/- 5% was 1.7% +/- 1.0%. The number of pixels with more than +/- 10% dose differences was negligible. An initial subset of hybrid plans was used to develop a quantitative criterion to verify for positional accuracy based on dosimetric verification of intensity map of IMRT plans for prostate patients in our institution. Plans with less than 5% of the pixels outside the +/- 5% dose-difference range were accepted. This method could be implemented for other anatomical sites or treatment planning and delivery systems.