| Literature DB >> 15527850 |
Richard Stebbings1, Neil Berry, Jim Stott, Robin Hull, Barry Walker, Jenny Lines, William Elsley, Stuart Brown, Alison Wade-Evans, Gail Davis, Jenny Cowie, Meera Sethi, Neil Almond.
Abstract
The identification of mechanisms that prevent infection with human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) would facilitate the development of an effective AIDS vaccine. In time-course experiments, protection against detectable superinfection with homologous wild-type SIV was achieved within 21 days of inoculation with live attenuated SIV, prior to the development of detectable anti-SIV humoral immunity. Partial protection against superinfection was achieved within 10 days of inoculation with live attenuated SIV, prior to the development of detectable anti-SIV humoral and cellular immunity. Furthermore, co-inoculation of live attenuated SIV with wild-type SIV resulted in a significant reduction in peak virus loads compared to controls that received wild-type SIV alone. These findings imply that innate immunity or non-immune mechanisms are a significant component of early protection against superinfection conferred by inoculation with live attenuated SIV.Entities:
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Year: 2004 PMID： 15527850 DOI： 10.1016/j.virol.2004.09.026
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616