Literature DB >> 15527761

Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line.

Teruki Oki1, Yoshihiro Sowa, Tohru Hirose, Nobumasa Takagaki, Mano Horinaka, Ryoko Nakanishi, Chikako Yasuda, Tatsushi Yoshida, Motohiro Kanazawa, Yoshiko Satomi, Hoyoku Nishino, Tsuneharu Miki, Toshiyuki Sakai.   

Abstract

Genistein is the most abundant isoflavone of soybeans and has been shown to cause growth arrest in various human cancer cell lines. However, the precise mechanism for this is still unclear. We report here that the growth arrest and DNA damage-inducible gene 45 (gadd45) gene is induced by genistein via its promoter in a DU145 human prostate cancer cell line. The binding of transcription factor nuclear factor-Y to the CCAAT site of the gadd45 promoter appears to be important for this activation by genistein.

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Year:  2004        PMID： 15527761     DOI： 10.1016/j.febslet.2004.09.085

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

Review 1.  GADD45 proteins: central players in tumorigenesis.

Authors:  R E Tamura; J F de Vasconcellos; D Sarkar; T A Libermann; P B Fisher; L F Zerbini
Journal:  Curr Mol Med       Date:  2012-06       Impact factor: 2.222

2.  ABCE1 plays an essential role in lung cancer progression and metastasis.

Authors:  Ye Tian; Xin Tian; Xu Han; Yong Chen; Cheng-Yang Song; Wen-Jun Jiang; Da-Li Tian
Journal:  Tumour Biol       Date:  2016-01-05

Review 3.  Soy isoflavones and prostate cancer: a review of molecular mechanisms.

Authors:  Abeer M Mahmoud; Wancai Yang; Maarten C Bosland
Journal:  J Steroid Biochem Mol Biol       Date:  2013-12-25       Impact factor: 4.292

Review 4.  Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR.

Authors:  Svjetlana Medjakovic; Monika Mueller; Alois Jungbauer
Journal:  Nutrients       Date:  2010-02-26       Impact factor: 5.717

Review 5.  New approaches to radiation protection.

Authors:  Eliot M Rosen; Regina Day; Vijay K Singh
Journal:  Front Oncol       Date:  2015-01-20       Impact factor: 6.244

6.  A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy.

Authors:  Yoshitaka Nakamura; Shingo Yogosawa; Yasuyuki Izutani; Hirotsuna Watanabe; Eigo Otsuji; Tosiyuki Sakai
Journal:  Mol Cancer       Date:  2009-11-12       Impact factor: 27.401

7.  The synergistic apoptotic interaction of Indole-3-Carbinol and Genistein with TRAIL on endometrial cancer cells.

Authors:  Bidur Parajuli; So-Jin Shin; Sang-Hoon Kwon; Soon-Do Cha; Hyun-Gyo Lee; Insoo Bae; Chi-Heum Cho
Journal:  J Korean Med Sci       Date:  2013-03-27       Impact factor: 2.153

8.  The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.

Authors:  Christian Ra Regenbrecht; Marc Jung; Hans Lehrach; James Adjaye
Journal:  BMC Med Genomics       Date:  2008-10-10       Impact factor: 3.063

9.  Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells.

Authors:  Qingxia Zhao; Ming Zhao; Amanda B Parris; Ying Xing; Xiaohe Yang
Journal:  Int J Oncol       Date:  2016-06-30       Impact factor: 5.650

10.  Genistein and AG1024 synergistically increase the radiosensitivity of prostate cancer cells.

Authors:  Qisheng Tang; Jianjun Ma; Jinbo Sun; Longfei Yang; Fan Yang; Wei Zhang; Ruixiao Li; Lei Wang; Yong Wang; He Wang
Journal:  Oncol Rep       Date:  2018-05-30       Impact factor: 3.906
  10 in total

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