| Literature DB >> 15527749 |
Atsushi Ono1, Yasunobu Okuma, Toru Hosoi, Yasuyuki Nomura.
Abstract
We investigated whether bacterial DNA (CpG-DNA)-induced IL-1beta expression in the mouse hypothalamus is mediated via afferent vagus nerve. Subdiaphragmatic vagotomy did not modify the CpG-DNA (i.p.)-induced IL-1beta expression in the hypothalamus, indicating that CpG-DNA-induced IL-1beta expression is independent of the afferent vagus nerve originating from the subdiaphragmatic organs. On the other hand, we observed the Toll-like receptor 9 mRNA expression in the hypothalamus, suggesting that circulating CpG-DNA acts directly in the brain.Entities:
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Year: 2004 PMID： 15527749 DOI： 10.1016/j.brainres.2004.09.006
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252