Literature DB >> 15527300

A scalable synthesis of a histamine H3 receptor antagonist.

Neelakandha S Mani1, Jill A Jablonowski, Todd K Jones.   

Abstract

Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.

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Year:  2004        PMID: 15527300     DOI: 10.1021/jo040225i

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  1 in total

1.  Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

Authors:  Pilho Kim; Liang Zhang; Ujjini H Manjunatha; Ramandeep Singh; Sejal Patel; Jan Jiricek; Thomas H Keller; Helena I Boshoff; Clifton E Barry; Cynthia S Dowd
Journal:  J Med Chem       Date:  2009-03-12       Impact factor: 7.446

  1 in total

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