Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.

Literature DB >> 15525550

11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.

Abstract

11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the interconversion of active cortisol and inert cortisone. Two isozymes have been discovered, each with unique properties and powerful biological roles. 11beta-HSD2 potently inactivates cortisol, protecting key tissues. By contrast, 11beta-HSD1 regenerates cortisol, amplifying its actions in liver, fat and brain. Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2004 PMID： 15525550 DOI： 10.1016/j.coph.2004.09.001

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

Keyword Cloud
Cited

56 in total

1. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats.

Authors: K Vinodraj; I M Nagendra Nayak; J Vikram Rao; Paul Mathai; N Chandralekha; B Nitasha; D Rajesh; T K Chethan
Journal: Indian J Pharmacol Date: 2015 Mar-Apr Impact factor: 1.200

Review 2. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function.

Authors: Karen E Chapman; Jonathan R Seckl
Journal: Neurochem Res Date: 2007-10-25 Impact factor: 3.996

3. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.

Authors: Peter D Gluckman; Karen A Lillycrop; Mark H Vickers; Anthony B Pleasants; Emma S Phillips; Alan S Beedle; Graham C Burdge; Mark A Hanson
Journal: Proc Natl Acad Sci U S A Date: 2007-07-23 Impact factor: 11.205

Review 4. Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation.

Authors: Per-Olof Hasselgren; Nima Alamdari; Zaira Aversa; Patricia Gonnella; Ira J Smith; Steven Tizio
Journal: Curr Opin Clin Nutr Metab Care Date: 2010-07 Impact factor: 4.294

5. Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults.

Authors: Benedict Herhaus; Katja Petrowski
Journal: Obes Facts Date: 2018-12-11 Impact factor: 3.942

Review 6. A users guide to HPA axis research.

Authors: Robert L Spencer; Terrence Deak
Journal: Physiol Behav Date: 2016-11-18

11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.

1. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats.

Review 2. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function.

3. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.

Review 4. Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation.

5. Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults.

Review 6. A users guide to HPA axis research.

7. Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes.

Review 8. Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment.

Review 9. Corticosteroids: Mechanisms of Action in Health and Disease.

10. The Role of Stress in Bipolar Disorder.