Literature DB >> 15525526

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint.

Conly L Rieder1, Helder Maiato.   

Abstract

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.

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Year:  2004        PMID： 15525526     DOI： 10.1016/j.devcel.2004.09.002

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  261 in total

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