Literature DB >> 15524472

Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.

G K Surya Prakash1, Jinbo Hu, Ying Wang, George A Olah.   

Abstract

A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluoromethyl anion ("CF(2)H(-)") equivalent.

Entities:  

Year:  2004        PMID： 15524472     DOI： 10.1021/ol048166i

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate.

Authors:  Petr Beier; Anastasia V Alexandrova; Mikhail Zibinsky; G K Surya Prakash
Journal:  Tetrahedron       Date:  2008-12       Impact factor: 2.457

2.  A Difluoromethylene Linchpin/Synthon: Application in Conjunction with Anion Relay Chemistry (ARC) Permits Ready Access to Diverse Difluoromethylene Scaffolds.

Authors:  Kevin T O'Brien; Jonathan W Nadraws; Amos B Smith
Journal:  Org Lett       Date:  2020-11-11       Impact factor: 6.005
  2 in total

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