Literature DB >> 15524443

Sialated diazeniumdiolate: a new sialidase-activated nitric oxide donor.

T Bill Cai1, Dongning Lu, Megan Landerholm, Peng George Wang.   

Abstract

A new sialated diazeniumdiolate has been synthesized, and the glycosylation product was exclusively an alpha anomer. This new nitric oxide donor exhibited significantly improved stability as compared to its parent diazeniumdiolate salts, and it could be efficiently hydrolyzed by neuraminidase to release nitric oxide with a K(m) of 0.14 mM. The sialic acid-NO conjugate would be a valuable prodrug that targets NO to influenza viruses.

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Year:  2004        PMID： 15524443     DOI： 10.1021/ol048397p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

Review 1.  Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy.

Authors:  Jihoon Kim; Bryant C Yung; Won Jong Kim; Xiaoyuan Chen
Journal:  J Control Release       Date:  2016-12-26       Impact factor: 9.776

2.  Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies.

Authors:  Yanhong Li; Hongzhi Cao; Hai Yu; Yi Chen; Kam Lau; Jingyao Qu; Vireak Thon; Go Sugiarto; Xi Chen
Journal:  Mol Biosyst       Date:  2011-01-04

3.  Nitrogen-bound diazeniumdiolated amidines.

Authors:  Debanjan Biswas; Jeffrey R Deschamps; Larry K Keefer; Joseph A Hrabie
Journal:  Chem Commun (Camb)       Date:  2010-06-30       Impact factor: 6.222

4.  One-pot SSA-catalyzed β-elimination: an efficient and inexpensive protocol for easy access to the glycal of sialic acid.

Authors:  Erickson M Paragas; I Abrrey Monreal; Chris M Vasil; Jonel P Saludes
Journal:  Carbohydr Res       Date:  2014-09-17       Impact factor: 2.104

5.  Glycosylated PROLI/NO derivatives as nitric oxide prodrugs.

Authors:  Rahul S Nandurdikar; Anna E Maciag; Sam Y Hong; Harinath Chakrapani; Michael L Citro; Larry K Keefer; Joseph E Saavedra
Journal:  Org Lett       Date:  2010-01-01       Impact factor: 6.005

6.  Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Authors:  Harinath Chakrapani; Thomas C Wilde; Michael L Citro; Michael M Goodblatt; Larry K Keefer; Joseph E Saavedra
Journal:  Bioorg Med Chem       Date:  2007-11-17       Impact factor: 3.641

7.  Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

Authors:  Harinath Chakrapani; Ravi C Kalathur; Anna E Maciag; Michael L Citro; Xinhua Ji; Larry K Keefer; Joseph E Saavedra
Journal:  Bioorg Med Chem       Date:  2008-09-30       Impact factor: 3.641

Review 8.  Heavy metal toxicity in plants and the potential NO-releasing novel techniques as the impending mitigation alternatives.

Authors:  Anjali Pande; Bong-Gyu Mun; Nusrat Jahan Methela; Waqas Rahim; Da-Sol Lee; Geun-Mo Lee; Jeum Kyu Hong; Adil Hussain; Gary Loake; Byung-Wook Yun
Journal:  Front Plant Sci       Date:  2022-09-23       Impact factor: 6.627

Review 9.  Progress and Promise of Nitric Oxide-Releasing Platforms.

Authors:  Tao Yang; Alexander N Zelikin; Rona Chandrawati
Journal:  Adv Sci (Weinh)       Date:  2018-04-23       Impact factor: 16.806

10.  Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.

Authors:  Livia S Zaramela; Cameron Martino; Frederico Alisson-Silva; Steven D Rees; Sandra L Diaz; Léa Chuzel; Mehul B Ganatra; Christopher H Taron; Patrick Secrest; Cristal Zuñiga; Jianbo Huang; Dionicio Siegel; Geoffrey Chang; Ajit Varki; Karsten Zengler
Journal:  Nat Microbiol       Date:  2019-09-23       Impact factor: 17.745
  10 in total

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