Literature DB >> 15523918

Folding and misfolding of the prion protein in the secretory pathway.

Jorg Tatzelt1, Konstanze F Winklhofer.   

Abstract

A hallmark of prion diseases in humans and animals is the conversion of the cellular prion protein PrPc to a pathogenic isoform, denoted PrPSc. PrPSc is characterized by distinct biochemical and biophysical properties; in addition, it is the major component of infectious prions. All available data indicate that the only difference between PrPc and PrPSc resides in their conformation, emphasizing a critical role of protein folding in the pathogenesis of prion diseases.

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Year:  2004        PMID： 15523918     DOI： 10.1080/1350-6120400000723

Source DB:  PubMed          Journal:  Amyloid        ISSN： 1350-6129            Impact factor:   7.141


  12 in total

1.  Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

Authors:  Angelika S Rambold; Margit Miesbauer; Doron Rapaport; Till Bartke; Michael Baier; Konstanze F Winklhofer; Jörg Tatzelt
Journal:  Mol Biol Cell       Date:  2006-05-17       Impact factor: 4.138

2.  alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum.

Authors:  Margit Miesbauer; Natalie V Pfeiffer; Angelika S Rambold; Veronika Müller; Sophia Kiachopoulos; Konstanze F Winklhofer; Jörg Tatzelt
Journal:  J Biol Chem       Date:  2009-06-26       Impact factor: 5.157

3.  Conserved stress-protective activity between prion protein and Shadoo.

Authors:  Vignesh Sakthivelu; Ralf P Seidel; Konstanze F Winklhofer; Jörg Tatzelt
Journal:  J Biol Chem       Date:  2011-01-21       Impact factor: 5.157

4.  Detection of proteinase K resistant proteins in the urine of patients with Creutzfeldt-Jakob and other neurodegenerative diseases.

Authors:  Reza Dabaghian; Inga Zerr; Uta Heinemann; Gianluigi Zanusso
Journal:  Prion       Date:  2008 Oct-Dec       Impact factor: 3.931

5.  Observing fibrillar assemblies on scrapie-infected cells.

Authors:  Susanne Wegmann; Margit Miesbauer; Konstanze F Winklhofer; Jörg Tatzelt; Daniel J Muller
Journal:  Pflugers Arch       Date:  2008-01-03       Impact factor: 3.657

6.  Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

Authors:  Anna D Engelke; Anika Gonsberg; Simrika Thapa; Sebastian Jung; Sarah Ulbrich; Ralf Seidel; Shaon Basu; Gerd Multhaup; Michael Baier; Martin Engelhard; Hermann M Schätzl; Konstanze F Winklhofer; Jörg Tatzelt
Journal:  J Biol Chem       Date:  2018-04-10       Impact factor: 5.157

7.  Overexpression of quality control proteins reduces prion conversion in prion-infected cells.

Authors:  Simrika Thapa; Basant Abdulrahman; Dalia H Abdelaziz; Li Lu; Manel Ben Aissa; Hermann M Schatzl
Journal:  J Biol Chem       Date:  2018-08-28       Impact factor: 5.157

8.  Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.

Authors:  Jin Zhang; Ke Wang; Yan Guo; Qi Shi; Chan Tian; Cao Chen; Chen Gao; Bao-Yun Zhang; Xiao-Ping Dong
Journal:  Virol J       Date:  2012-12-06       Impact factor: 4.099

Review 9.  Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion protein.

Authors:  Zhiqi Song; Deming Zhao; Lifeng Yang
Journal:  Neural Regen Res       Date:  2013-10-25       Impact factor: 5.135

Review 10.  Prion protein-Semisynthetic prion protein (PrP) variants with posttranslational modifications.

Authors:  Stefanie Hackl; Christian F W Becker
Journal:  J Pept Sci       Date:  2019-10       Impact factor: 1.905
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