PURPOSE OF REVIEW: A review of the current literature regarding the ocular manifestations and management of graft versus host disease is presented. RECENT FINDINGS: A variety of systemic and topical anti-inflammatory or immunomodulatory agents, including prednisolone acetate, cyclosporine A, FK506, autologous serum, and retinoic acid show promise in controlling ocular graft versus host disease. SUMMARY: Graft versus host disease is a common manifestation of allogeneic stem cell transplantation. Ocular manifestations are found in a majority of patients and may be the presenting symptom. Ocular findings include keratoconjunctivitis sicca, pseudomembranous conjunctivitis, corneal ulceration and perforation, and microvascular retinopathy. Systemic and local therapy may be used to control ocular disease.
PURPOSE OF REVIEW: A review of the current literature regarding the ocular manifestations and management of graft versus host disease is presented. RECENT FINDINGS: A variety of systemic and topical anti-inflammatory or immunomodulatory agents, including prednisolone acetate, cyclosporine A, FK506, autologous serum, and retinoic acid show promise in controlling ocular graft versus host disease. SUMMARY:Graft versus host disease is a common manifestation of allogeneic stem cell transplantation. Ocular manifestations are found in a majority of patients and may be the presenting symptom. Ocular findings include keratoconjunctivitis sicca, pseudomembranous conjunctivitis, corneal ulceration and perforation, and microvascular retinopathy. Systemic and local therapy may be used to control ocular disease.
Authors: Nora Mirza; Manfred Zierhut; Andreas Korn; Antje Bornemann; Wichard Vogel; Barbara Schmid-Horch; Wolfgang A Bethge; Stefan Stevanović; Helmut R Salih; Lothar Kanz; Hans-Georg Rammensee; Sebastian P Haen Journal: Proc Natl Acad Sci U S A Date: 2016-11-10 Impact factor: 11.205
Authors: Hsiu-Ju Yen; Hesham M Eissa; Neel S Bhatt; Sujuan Huang; Matthew J Ehrhardt; Nickhill Bhakta; Kirsten K Ness; Kevin R Krull; D Kumar Srivastava; Leslie L Robison; Melissa M Hudson; I-Chan Huang Journal: Blood Date: 2020-05-21 Impact factor: 22.113
Authors: Qing Pan; Adla Angelina; Andrea Zambrano; Michael Marrone; Walter J Stark; Thomas Heflin; Li Tang; Esen K Akpek Journal: Cochrane Database Syst Rev Date: 2013-08-27