| Literature DB >> 15522816 |
Jürgen Pohl1, Axel Ring, Thomas Hermann, Wolfgang Stremmel.
Abstract
Long-chain fatty acids (LCFAs) represent key metabolites for energy generation and storage. Transport and metabolism of LCFA are believed to be regulated by membrane-associated proteins that bind and transport LCFA. Identifying the postulated fatty acid transporters is of considerable interest since altered fatty acid uptake has been implicated in disease such as insulin resistance and obesity. Recently, a family of membrane associated proteins, termed fatty acid transport proteins (FATPs), have been described that enhance uptake of LCFAs. Until today, six members of this family, designated FATP1-6, have been characterized. This review will focus on FATP structure, expression patterns, regulation, mechanism of transport and clinical implications.Entities:
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Year: 2004 PMID： 15522816 DOI： 10.1016/j.bbalip.2004.06.004
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002