| Literature DB >> 15522212 |
Motohiro Yamamori1, Toshiyuki Sakaeda, Tsutomu Nakamura, Noboru Okamura, Takao Tamura, Nobuo Aoyama, Takashi Kamigaki, Masakazu Ohno, Toshiro Shirakawa, Akinobu Gotoh, Yoshikazu Kuroda, Masafumi Matsuo, Masato Kasuga, Katsuhiko Okumura.
Abstract
The mRNA expression of vascular endothelial growth factor (VEGF) was evaluated in colorectal adenocarcinomas and adjacent noncancerous colorectal tissues in 18 Japanese patients. The expression was confirmed to be up-regulated in the colorectal adenocarcinomas, when compared with the noncancerous tissues. Twelve genotypes of VEGF: six positions in the promoter region, two in the 5'UTR, and four in the 3'UTR, and their association with the expression of VEGF mRNA were evaluated. While G-1877A, T-1455C, G-1154A, C702T, and G1612A were not detected, C-2578A, T-1498C, G-1190A, C-634G, C-7T, C936T, and C1451T were found at allele frequencies of 4/36, 15/36, 15/36, 20/36, 8/36, 6/36, and 6/36, respectively, suggesting that C-2578A, G-1154A, and G1612A were associated with a decreased risk for colorectal adenocarcinoma. T-1498C (G-1190A) and C-7T were found to be associated with higher levels of VEGF mRNA, and may be a risk factor for the development of liver metastasis and/or prognosis of colorectal adenocarcinoma.Entities:
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Year: 2004 PMID： 15522212 DOI： 10.1016/j.bbrc.2004.10.005
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575