Literature DB >> 15522026

Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica.

Mizuki Yamada1, Naohito Hatta, Kana Sogo, Kazuhiro Komura, Yasuhito Hamaguchi, Kazuhiko Takehara.   

Abstract

BACKGROUND: Surgical treatment of a recessive dystrophic epidermolysis bullosa patient is very difficult for both the surgeon and the anesthetist because of the fragility of the skin and abnormal nature of the tumor bed.
OBJECTIVE: We report a case of 54-year-old Japanese recessive dystrophic epidermolysis bullosa patient with squamous cell carcinoma (SCC) of the lateral malleolus.
METHODS: A tumor measuring 5.0 x 5.5 cm was surgically excised. The defect was then reconstructed by full-thickness skin grafting. To avoid airway complications, general anesthesia was administered using a face mask. Because the regional lymph nodes were swollen before surgery, the patient underwent sentinel lymph node biopsy.
RESULTS: The patient remains well with no sign of recurrence or metastasis 7 months after surgery.
CONCLUSION: To preserve activities of daily living, surgery should be performed for squamous cell carcinomas arising in recessive dystrophic epidermolysis bullosa patients.

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Mesh:

Year:  2004        PMID: 15522026     DOI: 10.1111/j.1524-4725.2004.30440.x

Source DB:  PubMed          Journal:  Dermatol Surg        ISSN: 1076-0512            Impact factor:   3.398


  6 in total

1.  Surgical management of squamous cell carcinoma arising in patients affected by epidermolysis bullosa: a comparative study.

Authors:  Alessia Paganelli; Camilla Reggiani; Chiara Fiorentini; Mario Lando; Anna M Cesinaro; Cristina Magnoni
Journal:  Int Wound J       Date:  2020-01-15       Impact factor: 3.315

2.  Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance.

Authors:  Takenao Chino; Katsuto Tamai; Takehiko Yamazaki; Satoru Otsuru; Yasushi Kikuchi; Keisuke Nimura; Masayuki Endo; Miki Nagai; Jouni Uitto; Yasuo Kitajima; Yasufumi Kaneda
Journal:  Am J Pathol       Date:  2008-08-07       Impact factor: 4.307

Review 3.  Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature.

Authors:  Steve Kwon; Zhao Ming Dong; Peter C Wu
Journal:  World J Surg Oncol       Date:  2011-07-19       Impact factor: 2.754

Review 4.  Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases.

Authors:  H Montaudié; C Chiaverini; E Sbidian; A Charlesworth; J-P Lacour
Journal:  Orphanet J Rare Dis       Date:  2016-08-20       Impact factor: 4.123

5.  Surgical management and oncological follow-up of cutaneous squamous cell carcinomas arising in epidermolysis bullosa patients.

Authors:  Alessia Paganelli; Erminia Giordano; Chiara Fiorentini; Barbara Ferrari; Camilla Reggiani; Federico Garbarino; Cristina Magnoni
Journal:  Int J Dermatol       Date:  2022-03-22       Impact factor: 3.204

6.  Sentinel lymph node biopsy in nonmelanoma skin cancer patients.

Authors:  Marie-Laure Matthey-Giè; Ariane Boubaker; Igor Letovanec; Nicolas Demartines; Maurice Matter
Journal:  J Skin Cancer       Date:  2013-02-14
  6 in total

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