Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

Literature DB >> 15521747

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

Young Shin Cho¹, David A Carcache, Yuan Tian, Yue-Ming Li, Samuel J Danishefsky.

Abstract

We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15521747 DOI： 10.1021/ja045939p

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

14 in total

Review 1. Neurotrophic natural products: chemistry and biology.

Authors: Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal: Angew Chem Int Ed Engl Date: 2013-12-18 Impact factor: 15.336

2. Enantioselective total synthesis of (-)-jiadifenolide.

Authors: Jing Xu; Lynnie Trzoss; Weng K Chang; Emmanuel A Theodorakis
Journal: Angew Chem Int Ed Engl Date: 2011-03-11 Impact factor: 15.336

3. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.

Authors: Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal: Org Lett Date: 2011-08-03 Impact factor: 6.005

4. Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes.

Authors: Kevin Hung; Matthew L Condakes; Luiz F T Novaes; Stephen J Harwood; Takahiro Morikawa; Zhi Yang; Thomas J Maimone
Journal: J Am Chem Soc Date: 2019-02-11 Impact factor: 15.419

5. Synthesis of Neurotrophic Seco-prezizaane Sesquiterpenes (1R,10S)-2-Oxo-3,4-dehydroneomajucin, (2S)-Hydroxy-3,4-dehydroneomajucin, and (-)-Jiadifenin.

Authors: Xiayun Cheng; Glenn C Micalizio
Journal: J Am Chem Soc Date: 2016-01-25 Impact factor: 15.419

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

Review 1. Neurotrophic natural products: chemistry and biology.

2. Enantioselective total synthesis of (-)-jiadifenolide.

3. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.

4. Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes.

5. Synthesis of Neurotrophic Seco-prezizaane Sesquiterpenes (1R,10S)-2-Oxo-3,4-dehydroneomajucin, (2S)-Hydroxy-3,4-dehydroneomajucin, and (-)-Jiadifenin.

6. Contemporary Synthetic Strategies toward seco-Prezizaane Sesquiterpenes from Illicium Species.

7. Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.

8. Oxidative Entry into the Illicium Sesquiterpenes: Enantiospecific Synthesis of (+)-Pseudoanisatin.

9. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

10. Welwistatin support studies: expansion and limitation of aryllead(IV) coupling reactions.