Literature DB >> 15520854

p16 and ARF: activation of teenage proteins in old age.

Ande Satyanarayana1, K Lenhard Rudolph.   

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

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Year:  2004        PMID： 15520854      PMCID： PMC524239          DOI： 10.1172/JCI23437

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  30 in total

1.  A DNA damage checkpoint response in telomere-initiated senescence.

Authors:  Fabrizio d'Adda di Fagagna; Philip M Reaper; Lorena Clay-Farrace; Heike Fiegler; Philippa Carr; Thomas Von Zglinicki; Gabriele Saretzki; Nigel P Carter; Stephen P Jackson
Journal:  Nature       Date:  2003-11-05       Impact factor: 49.962

2.  Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling.

Authors:  A Satyanarayana; R A Greenberg; S Schaetzlein; J Buer; K Masutomi; W C Hahn; S Zimmermann; U Martens; M P Manns; K L Rudolph
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

3.  Activation of the DNA damage response by telomere attrition: a passage to cellular senescence.

Authors:  Philip M Reaper; Fabrizio d'Adda di Fagagna; Stephen P Jackson
Journal:  Cell Cycle       Date:  2004-05-08       Impact factor: 4.534

4.  Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.

Authors:  Q M Chen; J C Bartholomew; J Campisi; M Acosta; J D Reagan; B N Ames
Journal:  Biochem J       Date:  1998-05-15       Impact factor: 3.857

5.  p16INK4A participates in a G1 arrest checkpoint in response to DNA damage.

Authors:  G I Shapiro; C D Edwards; M E Ewen; B J Rollins
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

Review 6.  The biology of replicative senescence.

Authors:  J Campisi
Journal:  Eur J Cancer       Date:  1997-04       Impact factor: 9.162

7.  Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.

Authors:  G H Stein; L F Drullinger; A Soulard; V Dulić
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

8.  Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.

Authors:  Lin-Quan Sun; David W Lee; Quangeng Zhang; Weihong Xiao; Eric H Raabe; Alan Meeker; Dengshun Miao; David L Huso; Robert J Arceci
Journal:  Genes Dev       Date:  2004-04-22       Impact factor: 11.361

9.  Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.

Authors:  Olga A Sedelnikova; Izumi Horikawa; Drazen B Zimonjic; Nicholas C Popescu; William M Bonner; J Carl Barrett
Journal:  Nat Cell Biol       Date:  2004-02       Impact factor: 28.824

Review 10.  Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights.

Authors:  A Bartke; V Chandrashekar; F Dominici; D Turyn; B Kinney; R Steger; J J Kopchick
Journal:  Biogerontology       Date:  2003       Impact factor: 4.277
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  22 in total

1.  Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.

Authors:  Joonseok Cho; Hongmei Shen; Hui Yu; Hongjie Li; Tao Cheng; Sean Bong Lee; Byeong Chel Lee
Journal:  Blood       Date:  2010-10-28       Impact factor: 22.113

2.  Differential p53 engagement in response to oxidative and oncogenic stresses in Fanconi anemia mice.

Authors:  Reena Rani; Jie Li; Qishen Pang
Journal:  Cancer Res       Date:  2008-12-01       Impact factor: 12.701

Review 3.  Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung.

Authors:  Toru Nyunoya; Yohannes Mebratu; Amelia Contreras; Monica Delgado; Hitendra S Chand; Yohannes Tesfaigzi
Journal:  Am J Respir Cell Mol Biol       Date:  2014-03       Impact factor: 6.914

Review 4.  FoxOs: Unifying links between oxidative stress and skeletal homeostasis.

Authors:  Stavroula Kousteni
Journal:  Curr Osteoporos Rep       Date:  2011-06       Impact factor: 5.096

5.  FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.

Authors:  Marie-Therese Rached; Aruna Kode; Lili Xu; Yoshihiro Yoshikawa; Ji-Hye Paik; Ronald A Depinho; Stavroula Kousteni
Journal:  Cell Metab       Date:  2010-02-03       Impact factor: 27.287

Review 6.  Aging and Autophagy in the Heart.

Authors:  Akihiro Shirakabe; Yoshiyuki Ikeda; Sebastiano Sciarretta; Daniela K Zablocki; Junichi Sadoshima
Journal:  Circ Res       Date:  2016-05-13       Impact factor: 17.367

Review 7.  Roles of ARF tumour suppressor protein in lung cancer: time to hit the nail on the head!

Authors:  Ruju Vashi; Bhoomika M Patel
Journal:  Mol Cell Biochem       Date:  2021-01-03       Impact factor: 3.396

8.  Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD Severity.

Authors:  Jun-Ho Jang; Hitendra S Chand; Shannon Bruse; Melanie Doyle-Eisele; Christopher Royer; Jacob McDonald; Clifford Qualls; Aloysius J Klingelhutz; Yong Lin; Rama Mallampalli; Yohannes Tesfaigzi; Toru Nyunoya
Journal:  COPD       Date:  2016-12-27       Impact factor: 2.409

9.  Cigarette smoke induces cellular senescence.

Authors:  Toru Nyunoya; Martha M Monick; Aloysius Klingelhutz; Timur O Yarovinsky; Jeffrey R Cagley; Gary W Hunninghake
Journal:  Am J Respir Cell Mol Biol       Date:  2006-07-13       Impact factor: 6.914

10.  Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.

Authors:  Joon Seok Cho; Sung Ho Kook; Andria Rasile Robinson; Laura J Niedernhofer; Byeong-Chel Lee
Journal:  Stem Cells       Date:  2013-03       Impact factor: 6.277
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