Literature DB >> 15520512

Cholinesterase inhibiting withanolides from Withania somnifera.

Muhammad Iqbal Choudhary1, Sammer Yousuf, Sarfraz Ahmad Nawaz, Shakil Ahmed.   

Abstract

A total of two new (1, 2) and four known (3-6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6alpha,7alpha-epoxy-3beta,5alpha,20beta-trihydroxy-1-oxowitha-24-enolide (1), 5beta,6beta-epoxy-4beta,17alpha,27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-dihydrowithaferin-A (4), 6alpha,7alpha-epoxy-5alpha,20beta-dihydroxy-1-oxowitha-2,24-dienolide (5), and 5beta,6beta-epoxy-4beta-hydroxy-1-oxowitha-2,14,24-trienolide (6), respectively. Compounds 2, 3, 5, and 6 displayed inhibitory potential against butyrylcholinesterase, but only compounds 3, 4, and 6 were found to be active against acetylcholinesterase.

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Year:  2004        PMID： 15520512     DOI： 10.1248/cpb.52.1358

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  14 in total

1.  Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica.

Authors:  Toshihiro Murata; Erdenechimeg Selenge; Saki Oikawa; Keita Ageishi; Javzan Batkhuu; Kenroh Sasaki; Fumihiko Yoshizaki
Journal:  J Nat Med       Date:  2015-04-22       Impact factor: 2.343

2.  Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins.

Authors:  Ting-Zhuo Lv; Guang-Shun Wang
Journal:  Exp Ther Med       Date:  2015-05-07       Impact factor: 2.447

3.  Comparing the cytotoxic potential of Withania somnifera water and methanol extracts.

Authors:  Etheresia Pretorius; Hester Magdalena Oberholzer; Petrus Johannes Becker
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-05-07

4.  Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action.

Authors:  Ilkay Erdogan Orhan
Journal:  Curr Neuropharmacol       Date:  2013-07       Impact factor: 7.363

5.  Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells.

Authors:  Arpita Konar; Navjot Shah; Rumani Singh; Nishant Saxena; Sunil C Kaul; Renu Wadhwa; Mahendra K Thakur
Journal:  PLoS One       Date:  2011-11-11       Impact factor: 3.240

6.  Improved Agrobacterium rhizogenes-mediated hairy root culture system of Withania somnifera (L.) Dunal using sonication and heat treatment.

Authors:  Chandrasekaran Thilip; Chellappan Soundar Raju; Kandhan Varutharaju; Abubakker Aslam; Appakan Shajahan
Journal:  3 Biotech       Date:  2015-03-26       Impact factor: 2.406

7.  Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma.

Authors:  Lisette P Yco; Gabor Mocz; John Opoku-Ansah; André S Bachmann
Journal:  Biochem Insights       Date:  2014-11-09

Review 8.  Withania somnifera: Advances and Implementation of Molecular and Tissue Culture Techniques to Enhance Its Application.

Authors:  Vibha Pandey; Waquar Akhter Ansari; Pratibha Misra; Neelam Atri
Journal:  Front Plant Sci       Date:  2017-08-09       Impact factor: 5.753

9.  Anticholinesterase and antioxidant potentials of Nonea micrantha Bioss. & Reut along with GC-MS analysis.

Authors:  Muhammad Imran; Farhat Ullah; Muhammad Ayaz; Abdul Sadiq; Muhammad Raza Shah; Muhammad Saeed Jan; Farman Ullah
Journal:  BMC Complement Altern Med       Date:  2017-11-23       Impact factor: 3.659

Review 10.  Natural Withanolides in the Treatment of Chronic Diseases.

Authors:  Peter T White; Chitra Subramanian; Hashim F Motiwala; Mark S Cohen
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622
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