BACKGROUND: Patients with follicular (FL) or mantle cell lymphoma (MCL) are incurable with conventional therapy. We investigated the safety and efficacy of rituximab consolidation after autologous stem cell transplantation (ASCT) in order to prevent relapse by clearance of minimal residual disease (MRD). METHODS: Rituximab was given approximately 8 weeks after CD34+ cell enriched ASCT at 375 mg/m2, weekly for 4 weeks. Monitoring of MRD was performed by repetitive PCR analyses. RESULTS: Thirty-one patients were included; one died early after ASCT before rituximab administration. Thirty patients (20 FL, 10 MCL) were evaluable after rituximab consolidation, and 27 of these were assessable for MRD detection. Rituximab consolidation post-ASCT was safe, the most common toxicity being infection. At a median follow-up of 42 months (range 13-96) after ASCT, 25 patients were censored with an actuarial event-free survival (EFS) of 81% at 4 and 5 years. Four patients (two FL, two MCL) relapsed, and one additional MCL patient died unexpectedly in complete remission. PCR-negativity was observed in 22% of the patients before ASCT, 53% post-ASCT (P=0.0547), 72% after rituximab (P=0.0018) and 100% at 6 months post-transplant (P < 0.001). CONCLUSIONS: One single course of rituximab consolidation given after ASCT is safe, may help to eliminate MRD and may translate into improved EFS in both FL and MCL patients.
BACKGROUND:Patients with follicular (FL) or mantle cell lymphoma (MCL) are incurable with conventional therapy. We investigated the safety and efficacy of rituximab consolidation after autologous stem cell transplantation (ASCT) in order to prevent relapse by clearance of minimal residual disease (MRD). METHODS:Rituximab was given approximately 8 weeks after CD34+ cell enriched ASCT at 375 mg/m2, weekly for 4 weeks. Monitoring of MRD was performed by repetitive PCR analyses. RESULTS: Thirty-one patients were included; one died early after ASCT before rituximab administration. Thirty patients (20 FL, 10 MCL) were evaluable after rituximab consolidation, and 27 of these were assessable for MRD detection. Rituximab consolidation post-ASCT was safe, the most common toxicity being infection. At a median follow-up of 42 months (range 13-96) after ASCT, 25 patients were censored with an actuarial event-free survival (EFS) of 81% at 4 and 5 years. Four patients (two FL, two MCL) relapsed, and one additional MCLpatient died unexpectedly in complete remission. PCR-negativity was observed in 22% of the patients before ASCT, 53% post-ASCT (P=0.0547), 72% after rituximab (P=0.0018) and 100% at 6 months post-transplant (P < 0.001). CONCLUSIONS: One single course of rituximab consolidation given after ASCT is safe, may help to eliminate MRD and may translate into improved EFS in both FL and MCLpatients.
Authors: Samer A Srour; Shaoying Li; Uday R Popat; Muzaffar H Qazilbash; Sara Lozano-Cerrada; Farzeneh Maadani; Amin Alousi; Partow Kebriaei; Paolo Anderlini; Yago Nieto; Roy Jones; Elizabeth Shpall; Richard E Champlin; Chitra Hosing Journal: Br J Haematol Date: 2017-05-09 Impact factor: 6.998
Authors: Y L Kasamon; R J Jones; R A Brodsky; E J Fuchs; W Matsui; L Luznik; J D Powell; A L Blackford; A Goodrich; C D Gocke; R A Abrams; R F Ambinder; I W Flinn Journal: Ann Oncol Date: 2009-10-30 Impact factor: 32.976
Authors: S A Graf; P A Stevenson; L A Holmberg; B G Till; O W Press; T R Chauncey; S D Smith; M Philip; J J Orozco; A R Shustov; D J Green; E N Libby; W I Bensinger; J M Pagel; D G Maloney; Y Zhou; R D Cassaday; A K Gopal Journal: Ann Oncol Date: 2015-09-07 Impact factor: 32.976