BACKGROUND: Insulin-like growth factors (1GF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play important roles in cell growth and differentiation. The aim of this work was to investigate the roles of IGF-1 and IGFBP-3 in esophageal cancer. MATERIALS AND METHODS: We examined the circulating IGF-1 and IGFBP-3 concentration in 18 healthy controls and 66 esophageal cancer patients by ELISA and a ligand capture immunoassay. Immunohistochemistry for IGF-1 was performed on surgical specimens obtained from 93 patients with esophageal cancer. RESULTS: The serum IGF-1 and IGFBP-3 levels were significantly elevated in patients compared with healthy subjects and there was a positive correlation between IGF-1 and IGFBP-3. There was a significant correlation between IGF-1 level and depth of invasion and pathological stage. Poor prognosis was significantly correlated with increasing IGF-1 levels. The survival rates of high IGF-1 expression immunohistochemical study patients were poorer than those of low expression patients. CONCLUSION: Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1.
BACKGROUND: Insulin-like growth factors (1GF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play important roles in cell growth and differentiation. The aim of this work was to investigate the roles of IGF-1 and IGFBP-3 in esophageal cancer. MATERIALS AND METHODS: We examined the circulating IGF-1 and IGFBP-3 concentration in 18 healthy controls and 66 esophageal cancerpatients by ELISA and a ligand capture immunoassay. Immunohistochemistry for IGF-1 was performed on surgical specimens obtained from 93 patients with esophageal cancer. RESULTS: The serum IGF-1 and IGFBP-3 levels were significantly elevated in patients compared with healthy subjects and there was a positive correlation between IGF-1 and IGFBP-3. There was a significant correlation between IGF-1 level and depth of invasion and pathological stage. Poor prognosis was significantly correlated with increasing IGF-1 levels. The survival rates of high IGF-1 expression immunohistochemical study patients were poorer than those of low expression patients. CONCLUSION: Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1.
Authors: Lesley A Anderson; R G Peter Watson; Seamus J Murphy; Brian T Johnston; Harry Comber; Jim Mc Guigan; John V Reynolds; Liam J Murray Journal: World J Gastroenterol Date: 2007-03-14 Impact factor: 5.742
Authors: Amy L Myers; Lin Lin; Derek J Nancarrow; Zhuwen Wang; Daysha Ferrer-Torres; Dafydd G Thomas; Mark B Orringer; Jules Lin; Rishindra M Reddy; David G Beer; Andrew C Chang Journal: Oncotarget Date: 2015-09-22