Literature DB >> 15517507

Gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL): analysis of overdose cases reported to the Swiss Toxicological Information Centre.

Matthias E Liechti1, Hugo Kupferschmidt.   

Abstract

We analysed 141 cases of Gamma-hydroxybutyric acid (GHB) and Gamma-butyrolactone (GBL) intoxication reported by physicians to the Swiss Toxicological Information Centre between 1995 and 2003. GHB and GBL intoxication are associated with considerable morbidity. Multiple drug use is common. Overdosing frequently results in non-reactive coma, which accounts for the severity of the intoxication and the costs occasioned by management.

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Year:  2004        PMID： 15517507     DOI： 2004/35/smw-10697

Source DB:  PubMed          Journal:  Swiss Med Wkly        ISSN： 0036-7672            Impact factor:   2.193


  8 in total

1.  Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.

Authors:  Karen Gutscher; Christine Rauber-Lüthy; Marina Haller; Michèle Braun; Hugo Kupferschmidt; Gerd A Kullak-Ublick; Alessandro Ceschi
Journal:  Br J Clin Pharmacol       Date:  2013-01       Impact factor: 4.335

2.  Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between γ-hydroxybutyrate and L-lactate.

Authors:  Bridget L Morse; Nisha Vijay; Marilyn E Morris
Journal:  AAPS J       Date:  2014-05-23       Impact factor: 4.009

3.  Effect of chronic γ-hydroxybutyrate (GHB) administration on GHB toxicokinetics and GHB-induced respiratory depression.

Authors:  Bridget L Morse; Gurkishan S Chadha; Melanie A Felmlee; Kristin E Follman; Marilyn E Morris
Journal:  Am J Drug Alcohol Abuse       Date:  2017-06-29       Impact factor: 3.829

4.  Paracetamol orodispersible tablets: a risk for severe poisoning in children?

Authors:  Alessandro Ceschi; Katharina E Hofer; Christine Rauber-Lüthy; Hugo Kupferschmidt
Journal:  Eur J Clin Pharmacol       Date:  2010-11-23       Impact factor: 2.953

5.  Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects.

Authors:  Matthias E Liechti; Boris B Quednow; Evangelia Liakoni; Dario Dornbierer; Robin von Rotz; Maria Salomé Gachet; Jürg Gertsch; Erich Seifritz; Oliver G Bosch
Journal:  Br J Clin Pharmacol       Date:  2016-02-25       Impact factor: 4.335

6.  γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose.

Authors:  Bridget L Morse; Nisha Vijay; Marilyn E Morris
Journal:  Mol Pharmacol       Date:  2012-05-04       Impact factor: 4.436

7.  Rhabdomyolysis related to acute recreational drug toxicity-A Euro-DEN study.

Authors:  Wojciech Waldman; Piotr M Kabata; Alison M Dines; David M Wood; Christopher Yates; Fridtjof Heyerdahl; Knut Erik Hovda; Isabelle Giraudon; Paul I Dargan; Jacek Sein Anand
Journal:  PLoS One       Date:  2021-03-11       Impact factor: 3.240

8.  Repurposing of substances with lactone moiety for the treatment of γ-Hydroxybutyric acid and γ-Butyrolactone intoxication through modulating paraoxonase and PPARγ.

Authors:  Sepand Tehrani Fateh; Amir Salehi-Najafabadi
Journal:  Front Pharmacol       Date:  2022-07-22       Impact factor: 5.988
  8 in total

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