Literature DB >> 15517435

Olfactory function in patients with idiopathic Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus.

T Hummel1, U Jahnke, U Sommer, H Reichmann, A Müller.   

Abstract

Decrease of olfactory function in patients with Parkinson's disease (PD) is a well-investigated fact. The present study aimed to investigate olfaction in PD patients with a specific focus on the effects of deep brain stimulation in the subthalamic nucleus. Eleven patients (age 42-67 years) participated in this study. Using the "Sniffin' Sticks", olfactory function was assessed based on butanol odor thresholds and the patients' ability to discriminate odors. Measures were taken with the stimulator being switched ON and OFF, respectively. While deep brain stimulation had no effect on odor thresholds, in hyposmic PD patients odor discrimination was found to be significantly higher during the ON period. This may indicate that deep brain stimulation has a positive effect on the cognitive processing of olfactory information in PD patients.

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Year:  2004        PMID： 15517435     DOI： 10.1007/s00702-004-0207-y

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  17 in total

Review 1.  Premotor Diagnosis of Parkinson's Disease.

Authors:  Heinz Reichmann
Journal:  Neurosci Bull       Date:  2017-08-03       Impact factor: 5.203

2.  Effects of bilateral deep brain stimulation of the subthalamic nucleus on olfactory function in Parkinson's disease patients.

Authors:  Xiaodong Guo; Guodong Gao; Xuelian Wang; Lihong Li; Weixin Li; Qinchuan Liang; Hua Zhang
Journal:  Stereotact Funct Neurosurg       Date:  2008-05-13       Impact factor: 1.875

3.  Exploratory Investigation of a Brief Cognitive Behavioral Intervention and Transcranial Direct Current Stimulation on Odor Sensitivity.

Authors:  David C Houghton; Thomas W Uhde; Jeffrey J Borckardt; Bernadette M Cortese
Journal:  Psychosom Med       Date:  2019-05       Impact factor: 4.312

4.  [Olfactory dysfunction in neurodegenerative disorders].

Authors:  A Hähner; A Welge-Lüssen
Journal:  HNO       Date:  2010-07       Impact factor: 1.284

Review 5.  Olfactory dysfunction: common in later life and early warning of neurodegenerative disease.

Authors:  Karl-Bernd Hüttenbrink; Thomas Hummel; Daniela Berg; Thomas Gasser; Antje Hähner
Journal:  Dtsch Arztebl Int       Date:  2013-01-07       Impact factor: 5.594

6.  Neuroleptic-induced parkinsonism is associated with olfactory dysfunction.

Authors:  Stephanie Krüger; Antje Haehner; Claudia Thiem; Thomas Hummel
Journal:  J Neurol       Date:  2008-09-03       Impact factor: 4.849

7.  Early Parkinson's disease patients on rasagiline present with better odor discrimination.

Authors:  Antje Haehner; Angela Habersack; Miriam Wienecke; Alexander Storch; Heinz Reichmann; Thomas Hummel
Journal:  J Neural Transm (Vienna)       Date:  2015-07-30       Impact factor: 3.575

8.  Carbonic anhydrase I, II, and VI, blood plasma, erythrocyte and saliva zinc and copper increase after repetitive transcranial magnetic stimulation.

Authors:  Robert I Henkin; Samuel J Potolicchio; Lucien M Levy; Ramy Moharram; Irina Velicu; Brian M Martin
Journal:  Am J Med Sci       Date:  2010-03       Impact factor: 2.378

Review 9.  [Olfactory dysfunction in Parkinson's disease: its role as a new cardinal sign in early and differential diagnosis].

Authors:  B Herting; S Bietenbeck; K Scholz; A Hähner; T Hummel; H Reichmann
Journal:  Nervenarzt       Date:  2008-02       Impact factor: 1.214

10.  Olfactory training in patients with Parkinson's disease.

Authors:  Antje Haehner; Clara Tosch; Martin Wolz; Lisa Klingelhoefer; Mareike Fauser; Alexander Storch; Heinz Reichmann; Thomas Hummel
Journal:  PLoS One       Date:  2013-04-17       Impact factor: 3.240
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