Literature DB >> 15517414

Calcimimetics--fooling the calcium receptor.

Eberhard Ritz.   

Abstract

The cloning and characterization of a calcium-sensing receptor from bovine parathyroid cells has opened up the possibility of modulating the activity of this receptor protein by organic small molecules, either increasing the sensitivity for calcium (calcimimetics) or decreasing the sensitivity (calciolytics), thus suppressing or stimulating parathyroid hormone (PTH) secretion and synthesis, respectively. In primary and secondary hyperparathyroidism, calcimimetics have proven to effectively lower the PTH concentration with minimal side effects. In secondary hyperparathyroidism, a specific advantage is the concomitant lowering of serum calcium and phosphate concentrations.

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Year:  2004        PMID： 15517414     DOI： 10.1007/s00467-004-1671-1

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  33 in total

1.  The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism.

Authors:  Dolores M Shoback; John P Bilezikian; Stewart A Turner; Laura C McCary; Matthew D Guo; Munro Peacock
Journal:  J Clin Endocrinol Metab       Date:  2003-12       Impact factor: 5.958

Review 2.  Calcimimetics versus vitamin D: what are their relative roles?

Authors:  Tilman B Drüeke
Journal:  Blood Purif       Date:  2004       Impact factor: 2.614

3.  A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.

Authors:  Shengcheng Han; Ruhang Tang; Lisa K Anderson; Todd E Woerner; Zhen-Ming Pei
Journal:  Nature       Date:  2003-09-11       Impact factor: 49.962

4.  Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor.

Authors:  J Carl Pallais; Olga Kifor; Yi-Bin Chen; David Slovik; Edward M Brown
Journal:  N Engl J Med       Date:  2004-07-22       Impact factor: 91.245

5.  Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

Authors:  M Gowen; G B Stroup; R A Dodds; I E James; B J Votta; B R Smith; P K Bhatnagar; A M Lago; J F Callahan; E G DelMar; M A Miller; E F Nemeth; J Fox
Journal:  J Clin Invest       Date:  2000-06       Impact factor: 14.808

6.  Kinetics of serum 1,84 iPTH after high dose of calcitriol in uremic patients.

Authors:  A Seidel; P Herrmann; G Klaus; O Mehls; H Schmidt-Gayk; E Ritz
Journal:  Clin Nephrol       Date:  1993-04       Impact factor: 0.975

7.  Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.

Authors:  Christophe Petrel; Albane Kessler; Philippe Dauban; Robert H Dodd; Didier Rognan; Martial Ruat
Journal:  J Biol Chem       Date:  2004-02-19       Impact factor: 5.157

8.  Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized controlled trial.

Authors:  P R Holt; E O Atillasoy; J Gilman; J Guss; S F Moss; H Newmark; K Fan; K Yang; M Lipkin
Journal:  JAMA       Date:  1998 Sep 23-30       Impact factor: 56.272

Review 9.  Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.

Authors:  William G Goodman
Journal:  Pediatr Nephrol       Date:  2003-10-28       Impact factor: 3.714

10.  Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome.

Authors:  Rosa Vargas-Poussou; Chunfa Huang; Philippe Hulin; Pascal Houillier; Xavier Jeunemaître; Michel Paillard; Gabrielle Planelles; Michèle Déchaux; R Tyler Miller; Corinne Antignac
Journal:  J Am Soc Nephrol       Date:  2002-09       Impact factor: 10.121
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  2 in total

1.  Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia.

Authors:  Uri S Alon; René G VandeVoorde
Journal:  Pediatr Nephrol       Date:  2010-05-22       Impact factor: 3.714

2.  Cinacalcet is efficacious in pediatric dialysis patients.

Authors:  Douglas M Silverstein; Kanwal K Kher; Asha Moudgil; Mona Khurana; Jennifer Wilcox; Kathleen Moylan
Journal:  Pediatr Nephrol       Date:  2008-02-21       Impact factor: 3.714
  2 in total

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