Literature DB >> 15516994

Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

Philippe A Halban1.   

Abstract

Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regenerated beta cells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis.

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Year:  2004        PMID： 15516994     DOI： 10.1038/ncb1104-1021

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  21 in total

1.  Determination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated Islets.

Authors:  Daniel T Meier; Leon Entrup; Andrew T Templin; Meghan F Hogan; Thanya Samarasekera; Sakeneh Zraika; Edward J Boyko; Steven E Kahn
Journal:  J Histochem Cytochem       Date:  2015-08       Impact factor: 2.479

2.  Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells.

Authors:  Kohtaro Minami; Masaaki Okuno; Kazumasa Miyawaki; Akinori Okumachi; Katsuhiko Ishizaki; Kazunobu Oyama; Miho Kawaguchi; Nobuko Ishizuka; Toshihiko Iwanaga; Susumu Seino
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-06       Impact factor: 11.205

3.  The current status of islet transplantation and its perspectives.

Authors:  Naoya Kobayashi
Journal:  Rev Diabet Stud       Date:  2008-11-10

Review 4.  Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.

Authors:  Chris de Graaf; Dan Donnelly; Denise Wootten; Jesper Lau; Patrick M Sexton; Laurence J Miller; Jung-Mo Ahn; Jiayu Liao; Madeleine M Fletcher; Dehua Yang; Alastair J H Brown; Caihong Zhou; Jiejie Deng; Ming-Wei Wang
Journal:  Pharmacol Rev       Date:  2016-10       Impact factor: 25.468

Review 5.  Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer.

Authors:  M Mimeault; S K Batra
Journal:  Gut       Date:  2008-10       Impact factor: 23.059

6.  Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

Authors:  J J Meier; A Bhushan; A E Butler; R A Rizza; P C Butler
Journal:  Diabetologia       Date:  2005-10-05       Impact factor: 10.122

7.  GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).

Authors:  Jeffrey Stein; Wieslawa M Milewski; Manami Hara; Donald F Steiner; Arunangsu Dey
Journal:  Islets       Date:  2011-01-01       Impact factor: 2.694

8.  Amniotic fluid stem cells prevent β-cell injury.

Authors:  Valentina Villani; Anna Milanesi; Sargis Sedrakyan; Stefano Da Sacco; Susanne Angelow; Maria Teresa Conconi; Rosa Di Liddo; Roger De Filippo; Laura Perin
Journal:  Cytotherapy       Date:  2013-11-07       Impact factor: 5.414

9.  IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

Authors:  J Agudo; E Ayuso; V Jimenez; A Salavert; A Casellas; S Tafuro; V Haurigot; J Ruberte; J C Segovia; J Bueren; F Bosch
Journal:  Diabetologia       Date:  2008-07-29       Impact factor: 10.122

10.  Quantification and three-dimensional imaging of the insulitis-induced destruction of beta-cells in murine type 1 diabetes.

Authors:  Tomas Alanentalo; Andreas Hörnblad; Sofia Mayans; Anna Karin Nilsson; James Sharpe; Asa Larefalk; Ulf Ahlgren; Dan Holmberg
Journal:  Diabetes       Date:  2010-04-14       Impact factor: 9.461
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