Literature DB >> 15516762

A new steroidal saponin from Dioscorea cayenensis.

Marc Sautour1, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Alain Dongmo, Marie-Aleth Lacaille-Dubois.   

Abstract

The new 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 microg/ml, respectively), whereas saponins 1-3 were inactive.

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Year:  2004        PMID： 15516762     DOI： 10.1248/cpb.52.1353

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  10 in total

1.  Dioscin stimulates differentiation of mesenchymal stem cells towards hypertrophic chondrocytes in vitro and endochondral ossification in vivo.

Authors:  Murong You; Juehua Jing; Dasheng Tian; Jun Qian; Guangrong Yu
Journal:  Am J Transl Res       Date:  2016-09-15       Impact factor: 4.060

2.  Preparation of progenin III from total steroidal saponins of Dioscorea nipponica Makino using a crude enzyme from Aspergillus oryzae strain.

Authors:  Tingqiang Liu; Hongshan Yu; Chunying Liu; Yongming Bao; Xiangchun Hu; Yuanhao Wang; Bing Liu; Yaoyao Fu; Sihui Tang; Fengxie Jin
Journal:  J Ind Microbiol Biotechnol       Date:  2013-03-08       Impact factor: 3.346

3.  Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.

Authors:  Zulfiqar Ali; Troy J Smillie; Ikhlas A Khan
Journal:  Nat Prod Commun       Date:  2013-03       Impact factor: 0.986

4.  Characterization of steroidal saponins from Dioscorea villosa and D. cayenensis using ultrahigh performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry.

Authors:  Bharathi Avula; Yan-Hong Wang; Mei Wang; Zulfiqar Ali; Troy J Smillie; Jerry Zweigenbaum; Ikhlas A Khan
Journal:  Planta Med       Date:  2014-02-07       Impact factor: 3.352

5.  Bio-efficacy of Dioscorea pentaphylla from Midmid-Western Ghats, India.

Authors:  G Prakash; B B Hosetti
Journal:  Toxicol Int       Date:  2012-05

6.  Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs.

Authors:  Zhu-Jun Mao; Qian-Jue Tang; Ci-An Zhang; Zhi-Feng Qin; Bin Pang; Pin-Kang Wei; Bo Liu; Yuan-Neng Chou
Journal:  Int J Mol Sci       Date:  2012-05-24       Impact factor: 6.208

7.  Potent effects of dioscin against liver fibrosis.

Authors:  Xiaoling Zhang; Xu Han; Lianhong Yin; Lina Xu; Yan Qi; Youwei Xu; Huijun Sun; Yuan Lin; Kexin Liu; Jinyong Peng
Journal:  Sci Rep       Date:  2015-04-08       Impact factor: 4.379

8.  Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia.

Authors:  Le Zhang; Runfeng Ni; Jiani Li; Liwei Fan; Yanqi Song; Haijin Wang; Aidi Wang; Baoshan Liu
Journal:  Drug Des Devel Ther       Date:  2022-09-08       Impact factor: 4.319

9.  Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.

Authors:  Ming-Ju Hsieh; Te-Lung Tsai; Yih-Shou Hsieh; Chau-Jong Wang; Hui-Ling Chiou
Journal:  Arch Toxicol       Date:  2013-04-04       Impact factor: 5.153

10.  Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma.

Authors:  Wenli Mao; Heng Yin; Wenya Chen; Tingxiu Zhao; Shaofeng Wu; He Jin; Biaoyan Du; Yuhui Tan; Ren Zhang; Yanli He
Journal:  Drug Des Devel Ther       Date:  2020-05-28       Impact factor: 4.162
  10 in total

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