GOALS: To assess the influence of body mass index (BMI) in the outcome of liver transplantation. BACKGROUND: Body mass index appears to affect liver transplantation, independently of several risk factors. STUDY: A review of the United Network for Organ Sharing database included 32 515 liver transplants from 1992 through 2000 with at least one follow-up visit, of which 26 920 had information for determining BMI. The overall impact of elevated BMI (>25), and the impact of increasingly elevated BMI (25-40+) on graft failure rates and overall survival rates are assessed using proportional hazards regression. RESULTS: Controlling for follow-up time, age, gender, race, number of comorbidities, and status 1 designation, the impact of BMI on survival was mixed. The risk of death was elevated for patients with low BMI (<19) and BMI values of >/=40. Compared with patients with BMI of 19-22, those with BMI > 25 had a decreased likelihood of death. This decrease was seen among patients with BMI of 25-34. CONCLUSION: BMI did not significantly affect rates of graft failure. Compared with patients with a BMI in the 'normal' range, those with moderately elevated BMI had decreased likelihood of death while patients with low BMI or extremely high BMI had increased likelihood of death.
GOALS: To assess the influence of body mass index (BMI) in the outcome of liver transplantation. BACKGROUND: Body mass index appears to affect liver transplantation, independently of several risk factors. STUDY: A review of the United Network for Organ Sharing database included 32 515 liver transplants from 1992 through 2000 with at least one follow-up visit, of which 26 920 had information for determining BMI. The overall impact of elevated BMI (>25), and the impact of increasingly elevated BMI (25-40+) on graft failure rates and overall survival rates are assessed using proportional hazards regression. RESULTS: Controlling for follow-up time, age, gender, race, number of comorbidities, and status 1 designation, the impact of BMI on survival was mixed. The risk of death was elevated for patients with low BMI (<19) and BMI values of >/=40. Compared with patients with BMI of 19-22, those with BMI > 25 had a decreased likelihood of death. This decrease was seen among patients with BMI of 25-34. CONCLUSION: BMI did not significantly affect rates of graft failure. Compared with patients with a BMI in the 'normal' range, those with moderately elevated BMI had decreased likelihood of death while patients with low BMI or extremely high BMI had increased likelihood of death.
Authors: Trevor W Reichman; George Therapondos; Maria-Stella Serrano; John Seal; Rachel Evers-Meltzer; Humberto Bohorquez; Ari Cohen; Ian Carmody; Emily Ahmed; David Bruce; George E Loss Journal: World J Hepatol Date: 2015-06-18
Authors: Su-Hsin Chang; Xiaoyan Liu; Nils P Carlsson; Yikyung Park; Graham A Colditz; Jacqueline M Garonzik-Wang; William C Chapman; Jason R Wellen; Maria B Doyle; Tarek Alhamad Journal: Transplant Direct Date: 2017-06-12
Authors: Sven Pischke; Marie C Lege; Moritz von Wulffen; Antonio Galante; Benjamin Otto; Malte H Wehmeyer; Uta Herden; Lutz Fischer; Björn Nashan; Ansgar W Lohse; Martina Sterneck Journal: World J Hepatol Date: 2017-03-18