Literature DB >> 15515090

Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.

Andriy Luzhetskyy1, Tao Liu, Marta Fedoryshyn, Bohdan Ostash, Viktor Fedorenko, Jürgen Rohr, Andreas Bechthold.   

Abstract

The glycosyltransferase gene lanGT3, involved in the biosynthesis of the angucyclic antibiotic landomycin A, has been characterised by targeted gene deletion. A lanGT3 mutant was shown to produce landomycin E, which consists of a trisaccharide side chain attached to the polyketide moiety. Expression of lanGT3 in the mutant restored landomycin A production. Our results indicate that LanGT3 is responsible for the transfer of the fourth sugar during landomycin A biosynthesis.

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Year:  2004        PMID： 15515090     DOI： 10.1002/cbic.200400123

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  7 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
Journal:  J Nat Prod       Date:  2010-12-28       Impact factor: 4.050

2.  Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated.

Authors:  Tao Liu; Madan Kumar Kharel; Carsten Fischer; Andrew McCormick; Jürgen Rohr
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

3.  On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Authors:  Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-27       Impact factor: 15.336

Review 4.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

5.  Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.

Authors:  Lili Zhu; Andriy Luzhetskyy; Martha Luzhetska; Cynthia Mattingly; Val Adams; Andreas Bechthold; Jürgen Rohr
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

6.  Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

Authors:  David R Jackson; Xia Yu; Guojung Wang; Avinash B Patel; Jordi Calveras; Jesus F Barajas; Eita Sasaki; Mikko Metsä-Ketelä; Hung-Wen Liu; Jürgen Rohr; Shiou-Chuan Tsai
Journal:  ACS Chem Biol       Date:  2016-02-10       Impact factor: 5.100

7.  Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India.

Authors:  Priyanka Sharma; Debajit Thakur
Journal:  Sci Rep       Date:  2020-03-05       Impact factor: 4.379
  7 in total

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