Literature DB >> 15514708

Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats.

G N Kopylova1, S E Badmaeva, N G Levitskaya, G E Samonina, B A Umarova, A A Guseva.   

Abstract

Tripeptide PGP in a dose of 1 mg/kg had a correcting effect on behavioral disorders in rats induced by stress exposure (forced swimming). PGP prevented the increase in anxiety and decrease in orientation and exploratory activity. Our results suggest that the effect of this peptide is realized via central nervous structures involved in organism's response to stress factors.

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Year:  2004        PMID: 15514708     DOI: 10.1023/b:bebm.0000046923.37415.4e

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  1 in total

1.  Binding of tripeptide Pro-Gly-Pro labeled at the C-terminal proline residue to plasma membranes of the rat forebrain.

Authors:  T V V'unova; L A Andreeva; K V Shevchenko; V P Shevchenko; M Yu Bobrov; V V Bezuglov; N F Myasoedov
Journal:  Dokl Biol Sci       Date:  2008 Mar-Apr
  1 in total

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