| Literature DB >> 1551458 |
E Deudon1, E Berrou, M Breton, J Picard.
Abstract
1. The growth-stimulating effect of serum on the proteoglycan and hyaluronic acid production in arterial smooth muscle cells was investigated, using cells synchronized by serum deprivation. 2. After stimulation, synthesis of [35S]sulfated proteoglycans and [14C]hyaluronic acid increased during G1 and G2 phases (about 2- and 5-fold, respectively, in the culture medium), in comparison with quiescent cells. 3. Neither the size, nor the charge, nor the relative proportions of [35S]glycosaminoglycans of the proteoglycans were modified. 4. However, when the cells were stimulated to divide, increased synthesis of large [14C]hyaluronic acid was observed concomitantly with the production of higher hydrodynamic size [35S]proteoglycans, which aggregated with hyaluronic acid (20%).Entities:
Mesh：
Substances：
Year: 1992 PMID： 1551458 DOI： 10.1016/0020-711x(92)90040-8
Source DB: PubMed Journal: Int J Biochem ISSN： 0020-711X