OBJECTIVE: The authors examined the relationship between cholesterol metabolism and suicidality in carriers of Smith-Lemli-Opitz syndrome and their families. This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis. METHOD: Suicidal behavior, depression, misuse of alcohol and drugs, and family history of psychopathology, including attempted or completed suicide, were assessed by structured interview in 51 carriers of Smith-Lemli-Opitz syndrome and 54 matched comparison subjects. RESULTS: There were significantly more suicide attempters and completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects, but family history of psychopathology did not significantly differ between the groups. More suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects. CONCLUSIONS: These results, based on a unique study design, provide additional evidence supporting the relationship between cholesterol metabolism and suicidal behavior.
OBJECTIVE: The authors examined the relationship between cholesterol metabolism and suicidality in carriers of Smith-Lemli-Opitz syndrome and their families. This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis. METHOD: Suicidal behavior, depression, misuse of alcohol and drugs, and family history of psychopathology, including attempted or completed suicide, were assessed by structured interview in 51 carriers of Smith-Lemli-Opitz syndrome and 54 matched comparison subjects. RESULTS: There were significantly more suicide attempters and completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects, but family history of psychopathology did not significantly differ between the groups. More suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects. CONCLUSIONS: These results, based on a unique study design, provide additional evidence supporting the relationship between cholesterol metabolism and suicidal behavior.
Authors: Keith W McLarren; Tesa M Severson; Christèle du Souich; David W Stockton; Lisa E Kratz; David Cunningham; Glenda Hendson; Ryan D Morin; Diane Wu; Jessica E Paul; Jianghong An; Tanya N Nelson; Athena Chou; Andrea E DeBarber; Louise S Merkens; Jacques L Michaud; Paula J Waters; Jingyi Yin; Barbara McGillivray; Michelle Demos; Guy A Rouleau; Karl-Heinz Grzeschik; Raffaella Smith; Patrick S Tarpey; Debbie Shears; Charles E Schwartz; Jozef Gecz; Michael R Stratton; Laura Arbour; Jane Hurlburt; Margot I Van Allen; Gail E Herman; Yongjun Zhao; Richard Moore; Richard I Kelley; Steven J M Jones; Robert D Steiner; F Lucy Raymond; Marco A Marra; Cornelius F Boerkoel Journal: Am J Hum Genet Date: 2010-12-10 Impact factor: 11.025
Authors: Daniel C Mathews; Erica M Richards; Mark J Niciu; Dawn F Ionescu; Joseph J Rasimas; Carlos A Zarate Journal: Transl Neurosci Date: 2013-06 Impact factor: 1.757
Authors: Gil Zalsman; Mark J Mann; Yung-Yu Huang; Maria A Oquendo; David A Brent; Ainsley K Burke; Steven P Ellis; J John Mann Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2009-03-26 Impact factor: 5.067