OBJECTIVE: The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism. METHOD: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of D-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist. RESULTS: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. d-Cycloserine was well tolerated at most of the doses used in this study. CONCLUSIONS: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted.
RCT Entities:
OBJECTIVE: The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism. METHOD: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of D-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist. RESULTS: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. d-Cycloserine was well tolerated at most of the doses used in this study. CONCLUSIONS: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted.
Authors: Logan K Wink; Martin H Plawecki; Craig A Erickson; Kimberly A Stigler; Christopher J McDougle Journal: Expert Opin Emerg Drugs Date: 2010-09 Impact factor: 4.191
Authors: Craig A Erickson; David J Posey; Kimberly A Stigler; Jennifer Mullett; Adrian R Katschke; Christopher J McDougle Journal: Psychopharmacology (Berl) Date: 2006-10-03 Impact factor: 4.530
Authors: Hannah Schoch; Arati S Kreibich; Sarah L Ferri; Rachel S White; Dominique Bohorquez; Anamika Banerjee; Russell G Port; Holly C Dow; Lucero Cordero; Ashley A Pallathra; Hyong Kim; Hongzhe Li; Warren B Bilker; Shinji Hirano; Robert T Schultz; Karin Borgmann-Winter; Chang-Gyu Hahn; Dirk Feldmeyer; Gregory C Carlson; Ted Abel; Edward S Brodkin Journal: Biol Psychiatry Date: 2016-06-16 Impact factor: 13.382