Literature DB >> 15512828

Viral load of human herpesvirus 8 (HHV-8) in the circulatory blood cells correlates with clinical progression in a patient with HHV-8-associated solid lymphoma with aids-associated Kaposi's sarcoma.

Jian Song1, Atsushi Yoshida, Yoshihiko Yamamoto, Harutaka Katano, Keisuke Hagihara, Shinichi Oka, Satoshi Kimura, Kazuyuki Yoshizaki.   

Abstract

We encountered a case of a rapidly progressive HHV-8-associated solid lymphoma with AIDS-associated Kaposi's sarcoma (KS). HHV-8 DNA load in whole blood cells was analyzed quantitatively by real-time PCR using amplification of the HHV-8-encoded ORF26 gene. Ours is the first observation that the rapid increase in the HHV-8 viral load (from 1.9x10(4) copies/microg to 1.6x10(6) copies/microg in 40 days) in conjunction with low CD4+ cell counts was accompanied by an accelerated clinical disease progression. The results indicate that the quantity of circulating HHV-8 is measurable with real-time PCR and can provide clinically useful information.

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Year:  2004        PMID： 15512828     DOI： 10.1080/10428190412331283242

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  9 in total

1.  FoxO1 Suppresses Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency.

Authors:  Ruoyun Gao; Tingting Li; Brandon Tan; Suzane Ramos da Silva; Jae U Jung; Pinghui Feng; Shou-Jiang Gao
Journal:  J Virol       Date:  2019-01-17       Impact factor: 5.103

2.  A novel role of hydrogen peroxide in Kaposi sarcoma-associated herpesvirus reactivation.

Authors:  Fengchun Ye; Shou-Jiang Gao
Journal:  Cell Cycle       Date:  2011-10-01       Impact factor: 4.534

3.  Virological and molecular characterization of Kaposi's sarcoma-associated herpesvirus strains from Xinjiang, China.

Authors:  X Wang; H Wang; B He; Y Hui; G Lv; L Li; H Wen
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-05-03       Impact factor: 3.267

4.  Replication and transcription activator (RTA) of murine gammaherpesvirus 68 binds to an RTA-responsive element and activates the expression of ORF18.

Authors:  Yun Hong; Jing Qi; Danyang Gong; Chuanhui Han; Hongyu Deng
Journal:  J Virol       Date:  2011-08-17       Impact factor: 5.103

5.  Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation.

Authors:  Fengchun Ye; Xiufen Lei; Shou-Jiang Gao
Journal:  Adv Virol       Date:  2011

6.  KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

Authors:  Fang Cheng; Magdalena Weidner-Glunde; Markku Varjosalo; Eeva-Marja Rainio; Anne Lehtonen; Thomas F Schulz; Päivi J Koskinen; Jussi Taipale; Päivi M Ojala
Journal:  PLoS Pathog       Date:  2009-03-06       Impact factor: 6.823

7.  Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Authors:  Giuseppe Balistreri; Johanna Viiliäinen; Mikko Turunen; Raquel Diaz; Lauri Lyly; Pirita Pekkonen; Juha Rantala; Krista Ojala; Grzegorz Sarek; Mari Teesalu; Oxana Denisova; Karita Peltonen; Ilkka Julkunen; Markku Varjosalo; Denis Kainov; Olli Kallioniemi; Marikki Laiho; Jussi Taipale; Sampsa Hautaniemi; Päivi M Ojala
Journal:  PLoS Pathog       Date:  2016-02-18       Impact factor: 6.823

Review 8.  Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease.

Authors:  Marshall V Williams; Brandon Cox; Maria Eugenia Ariza
Journal:  Pathogens       Date:  2016-12-28

9.  Nucleolar stress enhances lytic reactivation of the Kaposi's sarcoma-associated herpesvirus.

Authors:  Anastasia Gelgor; Chen Gam Ze Letova; Yana Yegorov; Inna Kalt; Ronit Sarid
Journal:  Oncotarget       Date:  2018-02-15
  9 in total

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