Advanced cervical carcinoma in Ibadan, Nigeria: an appraisal of radiation therapy.

This is a retrospective study of 500 patients with advanced cervical cancer (FIGO Stages IIB, III and IVA) who were seen and managed at the University College Hospital Ibadan between 1988 and 1992. External pelvic radiation therapy plus intractivary radioactive caesium brachytherapy was mainstay of treatment. Complete response to therapy was recorded in 68% of patients with stage IIB, 57% in stage III and 41.2% of patients in stage IVA. In patients with stage IIB, the local tumour control was 65%, in stage III patients 54% and in patients with stage IV 41%. The cumulative rates of survival at 5 years (for all the patients-with stage IIB, III and IVa) were 41.5%. The cumulative rates for disease-free survival at 5 years was 25.5%. Radiotherapy as the sole treatment modality in the management of advanced cervical cancer in Ibadan has yielded poor results as revealed in this study. There is an urgent need to evolve a new treatment policy with the aim of improving the response rate and survival in this group of patients.