Literature DB >> 15511662

Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation.

Carsten B Schmidt-Weber1, Kurt Blaser.   

Abstract

Transforming growth factor-beta (TGF-beta) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-beta in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-beta in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-beta; however, TGF-beta-mediated tissue remodelling can be a serious complication in such diseases.

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Year:  2004        PMID： 15511662     DOI： 10.1016/j.coi.2004.09.008

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  29 in total

1.  Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25.

Authors:  Lisa G Gregory; Sara A Mathie; Simone A Walker; Sophie Pegorier; Carla P Jones; Clare M Lloyd
Journal:  Am J Respir Crit Care Med       Date:  2010-03-25       Impact factor: 21.405

2.  Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis.

Authors:  Henry W Murray; Kathleen C Flanders; Debra D Donaldson; Joseph P Sypek; Philip J Gotwals; Jianguo Liu; Xiaojing Ma
Journal:  Infect Immun       Date:  2005-07       Impact factor: 3.441

3.  The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.

Authors:  Mojca Skoberne; Selin Somersan; Wanda Almodovar; Tuan Truong; Kseniya Petrova; Peter M Henson; Nina Bhardwaj
Journal:  Blood       Date:  2006-04-13       Impact factor: 22.113

4.  Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma.

Authors:  Alfons Torrego; Mark Hew; Tim Oates; Maria Sukkar; Kian Fan Chung
Journal:  Thorax       Date:  2007-01-24       Impact factor: 9.139

Review 5.  Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.

Authors:  Laura E Nagy; Wen-Xing Ding; Gail Cresci; Paramananda Saikia; Vijay H Shah
Journal:  Gastroenterology       Date:  2016-02-23       Impact factor: 22.682

6.  Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.

Authors:  Farai Gombedza; Vinay Kondeti; Nosayba Al-Azzam; Stephanie Koppes; Ernest Duah; Prachi Patil; Madison Hexter; Daniel Phillips; Charles K Thodeti; Sailaja Paruchuri
Journal:  FASEB J       Date:  2017-01-10       Impact factor: 5.191

7.  Molecular imaging of TGFβ-induced Smad2/3 phosphorylation reveals a role for receptor tyrosine kinases in modulating TGFβ signaling.

Authors:  Shyam Nyati; Katrina Schinske; Dipankar Ray; Mukesh K Nyati; Mukesh Nyati; Brian Dale Ross; Alnawaz Rehemtulla
Journal:  Clin Cancer Res       Date:  2011-09-26       Impact factor: 12.531

8.  The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells.

Authors:  Song Guo Zheng
Journal:  Int J Clin Exp Med       Date:  2008-06-10

9.  Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF).

Authors:  Sophie Pegorier; Gaynor A Campbell; A Barry Kay; Clare M Lloyd
Journal:  Respir Res       Date:  2010-06-23

10.  The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

Authors:  Anthony M Ford; Chiara Palmi; Clara Bueno; Dengli Hong; Penny Cardus; Deborah Knight; Giovanni Cazzaniga; Tariq Enver; Mel Greaves
Journal:  J Clin Invest       Date:  2009-03-16       Impact factor: 14.808
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