Literature DB >> 15509155

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs.

Maria C Breschi1, Vincenzo Calderone, Maria Digiacomo, Alma Martelli, Enrica Martinotti, Filippo Minutolo, Simona Rapposelli, Aldo Balsamo.   

Abstract

The aim of this work was to develop lead pharmacodynamic hybrids, NO-sartans, possessing the characteristics of a typical AT1-antagonist and of a "slow NO donor", by adding NO-donor side chains to losartan. These new compounds, 2a and 2b, displayed vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of angiotensin II, with potency values similar to that of losartan. In vivo, the antihypertensive effects of 2a were similar to those of losartan and captopril.

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Year:  2004        PMID： 15509155     DOI： 10.1021/jm049681p

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

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Authors:  Koichi Yamamoto; Mitsuru Ohishi; Christopher Ho; Theodore W Kurtz; Hiromi Rakugi
Journal:  Hypertension       Date:  2009-10-12       Impact factor: 10.190

2.  Synthesis and Evaluation of [18F]FEtLos and [18F]AMBF3Los as Novel 18F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors.

Authors:  Martha Sahylí Ortega Pijeira; Paulo Sérgio Gonçalves Nunes; Sofia Nascimento Dos Santos; Zhengxing Zhang; Arian Pérez Nario; Efrain Araujo Perini; Walter Miguel Turato; Zalua Rodríguez Riera; Roger Chammas; Philip H Elsinga; Kuo-Shyan Lin; Ivone Carvalho; Emerson Soares Bernardes
Journal:  Molecules       Date:  2020-04-18       Impact factor: 4.411

3.  Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function.

Authors:  Alma Martelli; Lorenzo Flori; Era Gorica; Eugenia Piragine; Anella Saviano; Giuseppe Annunziata; Matteo Nicola Dario Di Minno; Roberto Ciampaglia; Ilenia Calcaterra; Francesco Maione; Gian Carlo Tenore; Ettore Novellino; Vincenzo Calderone
Journal:  Nutrients       Date:  2021-05-02       Impact factor: 5.717
  3 in total

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