OBJECTIVE: The purpose of this study was to evaluate neurodevelopmental outcome in extremely-low-birth-weight (ELBW) infants, all of whom had 3 characteristics: gestational age (GA) < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar score < or =3. STUDY DESIGN: Surviving infants were evaluated at 18 to 22 months' corrected age with a neurologic examination and the Bayley II Mental and Psychomotor Developmental Index (MDI and PDI). RESULTS: Between 1993 and 1999, 1016 infants had GA < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar score < or =3. Of 246 survivors, 30% had cerebral palsy (CP), 5% had hearing impairment, and 2% were blind. MDI was > or =85 in 33% and < 70 in 46% of infants, while PDI was > or =85 in 41% and < 70 in 36% infants. Predictors of MDI < 70 were grade III-IV ICH, cystic periventricular leukomalacia (PVL), male gender, black race, and Medicaid insurance. Two-parent household was associated with an MDI >70. Predictors of PDI < 70 were grade III-IV ICH, PVL, steroids for bronchopulmonary dysplasia (BPD), and Medicaid insurance. CP was associated with grade III-IV ICH and PVL. CONCLUSION: Perinatologists and neonatologists should be aware of the risk of morbidity and mortality in this high-risk ELBW group.
OBJECTIVE: The purpose of this study was to evaluate neurodevelopmental outcome in extremely-low-birth-weight (ELBW) infants, all of whom had 3 characteristics: gestational age (GA) < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar score < or =3. STUDY DESIGN: Surviving infants were evaluated at 18 to 22 months' corrected age with a neurologic examination and the Bayley II Mental and Psychomotor Developmental Index (MDI and PDI). RESULTS: Between 1993 and 1999, 1016 infants had GA < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar score < or =3. Of 246 survivors, 30% had cerebral palsy (CP), 5% had hearing impairment, and 2% were blind. MDI was > or =85 in 33% and < 70 in 46% of infants, while PDI was > or =85 in 41% and < 70 in 36% infants. Predictors of MDI < 70 were grade III-IV ICH, cystic periventricular leukomalacia (PVL), male gender, black race, and Medicaid insurance. Two-parent household was associated with an MDI >70. Predictors of PDI < 70 were grade III-IV ICH, PVL, steroids for bronchopulmonary dysplasia (BPD), and Medicaid insurance. CP was associated with grade III-IV ICH and PVL. CONCLUSION: Perinatologists and neonatologists should be aware of the risk of morbidity and mortality in this high-risk ELBW group.
Authors: Myra H Wyckoff; Walid A Salhab; Roy J Heyne; Douglas E Kendrick; Barbara J Stoll; Abbot R Laptook Journal: J Pediatr Date: 2011-09-17 Impact factor: 4.406
Authors: Carla Arpino; Eliana Compagnone; Maria L Montanaro; Denise Cacciatore; Angela De Luca; Angelica Cerulli; Stefano Di Girolamo; Paolo Curatolo Journal: Childs Nerv Syst Date: 2010-03-27 Impact factor: 1.475
Authors: Jennifer B Helderman; Thomas M O'Shea; Karl C K Kuban; Elizabeth N Allred; Jonathan L Hecht; Olaf Dammann; Nigel Paneth; T F McElrath; Andrew Onderdonk; Alan Leviton Journal: Pediatrics Date: 2012-02-13 Impact factor: 7.124
Authors: Karl C K Kuban; Elizabeth N Allred; T Michael O'Shea; Nigel Paneth; Marcello Pagano; Olaf Dammann; Alan Leviton; Adré Du Plessis; Sjirk J Westra; Cindy R Miller; Haim Bassan; Kalpathy Krishnamoorthy; Joseph Junewick; Nicholas Olomu; Elaine Romano; Joanna Seibert; Steve Engelke; Padmani Karna; Daniel Batton; Sunila E O'Connor; Cecelia E Keller Journal: J Child Neurol Date: 2009-01 Impact factor: 1.987