Literature DB >> 1550698

Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.

M Pirmohamed1, N R Kitteringham, A M Breckenridge, B K Park.   

Abstract

A 16-year old patient with carbamazepine-induced hepatotoxicity, associated with the hypersensitivity manifestations of fever, rash and eosinophilia, is described. Mononuclear leucocytes from the patient were more sensitive to oxidative metabolites of carbamazepine generated by induced murine and human hepatic microsomes, than cells from controls. On immunoblot analysis, serum from the patient recognised a single protein band (94 kDa) on human liver microsomes, but none out of 25 control sera recognised this band. No bands were recognised by the patient serum on human kidney microsomes or on microsomes from mouse and rat liver.

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Year:  1992        PMID： 1550698      PMCID： PMC1381305          DOI： 10.1111/j.1365-2125.1992.tb04022.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  15 in total

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Review 2.  Drug disposition and drug hypersensitivity.

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5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

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6.  Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

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7.  Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

Authors:  M Pirmohamed; A Graham; P Roberts; D Smith; D Chadwick; A M Breckenridge; B K Park
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8.  Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

Authors:  P Beaune; P M Dansette; D Mansuy; L Kiffel; M Finck; C Amar; J P Leroux; J C Homberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

9.  An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

Authors:  R J Riley; J L Maggs; C Lambert; N R Kitteringham; B K Park
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Review 10.  Hepatic considerations in the use of antiepileptic drugs.

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  6 in total

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Review 4.  Genetically determined adverse drug reactions involving metabolism.

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Journal:  Drug Saf       Date:  1993-07       Impact factor: 5.606

5.  Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.

Authors:  N R Kitteringham; J G Kenna; B K Park
Journal:  Br J Clin Pharmacol       Date:  1995-10       Impact factor: 4.335

6.  Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy.

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  6 in total

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