Literature DB >> 15506948

Folate and DNA methylation during in utero development and aging.

J A McKay1, E A Williams, J C Mathers.   

Abstract

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging, including cancer and cardiovascular and neurological diseases. Evidence is accumulating that dietary factors in utero modulate disease risk in later life. Although folic acid is a key component of DNA methylation, the impact of folic acid availability in utero on DNA methylation patterns and disease risk in adulthood is at present poorly characterized. This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging.

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Year:  2004        PMID： 15506948     DOI： 10.1042/BST0321006

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  14 in total

1.  Environment and origin of disease.

Authors:  Vasantha Padmanabhan
Journal:  Rev Endocr Metab Disord       Date:  2007-06       Impact factor: 6.514

Review 2.  Impact of epigenetic dietary compounds on transgenerational prevention of human diseases.

Authors:  Yuanyuan Li; Sabita N Saldanha; Trygve O Tollefsbol
Journal:  AAPS J       Date:  2013-10-11       Impact factor: 4.009

3.  Association of genomic instability, and the methylation status of imprinted genes and mismatch-repair genes, with neural tube defects.

Authors:  Zhuo Liu; Zhigang Wang; Yuanyuan Li; Shengrong Ouyang; Huibo Chang; Ting Zhang; Xiaoying Zheng; Jianxin Wu
Journal:  Eur J Hum Genet       Date:  2012-01-11       Impact factor: 4.246

4.  Dietary intake of B-vitamins in mothers born a child with a congenital heart defect.

Authors:  Anna C Verkleij-Hagoort; Jeanne H M de Vries; Nicolette T C Ursem; Robert de Jonge; Wim C J Hop; Régine P M Steegers-Theunissen
Journal:  Eur J Nutr       Date:  2006-11-21       Impact factor: 5.614

Review 5.  Epigenetic dysfunctional diseases and therapy for infection and inflammation.

Authors:  Saheli Samanta; Sheeja Rajasingh; Thuy Cao; Buddhadeb Dawn; Johnson Rajasingh
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2016-12-03       Impact factor: 5.187

Review 6.  Pharmacology of epigenetics in brain disorders.

Authors:  Pritika Narayan; Mike Dragunow
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739

7.  DNA methylation program during development.

Authors:  Feng C Zhou
Journal:  Front Biol (Beijing)       Date:  2012-12-01

Review 8.  Gene expression in the placenta: maternal stress and epigenetic responses.

Authors:  Ciprian P Gheorghe; Ravi Goyal; Ashwani Mittal; Lawrence D Longo
Journal:  Int J Dev Biol       Date:  2010       Impact factor: 2.203

Review 9.  DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging.

Authors:  Kyong-chol Kim; Simonetta Friso; Sang-Woon Choi
Journal:  J Nutr Biochem       Date:  2009-09-04       Impact factor: 6.048

10.  A role for Drosophila in understanding drug-induced cytotoxicity and teratogenesis.

Authors:  Joslynn G Affleck; Virginia K Walker
Journal:  Cytotechnology       Date:  2008-01-30       Impact factor: 2.058
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