Literature DB >> 15506934

Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.

H W Mankouri1, I D Hickson.   

Abstract

RecQ helicases are evolutionarily conserved enzymes required for the maintenance of genome stability. Mutations in three of the five known human RecQ helicase genes cause distinct clinical disorders that are characterized by genome instability and cancer predisposition. Recent studies have begun to reveal the cellular roles of RecQ helicases and how these enzymes may prevent tumorigenesis at the molecular level.

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Year:  2004        PMID： 15506934     DOI： 10.1042/BST0320957

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  11 in total

Review 1.  Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.

Authors:  Sudha Sharma; Kevin M Doherty; Robert M Brosh
Journal:  Biochem J       Date:  2006-09-15       Impact factor: 3.857

2.  Resolution of converging replication forks by RecQ and topoisomerase III.

Authors:  Catherine Suski; Kenneth J Marians
Journal:  Mol Cell       Date:  2008-06-20       Impact factor: 17.970

3.  Genome instability and embryonic developmental defects in RMI1 deficient mice.

Authors:  Michel F Guiraldelli; Craig Eyster; Roberto J Pezza
Journal:  DNA Repair (Amst)       Date:  2013-07-27

4.  Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage.

Authors:  Sonja Flott; John Rouse
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

5.  WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3.

Authors:  Monika Aggarwal; Robert M Brosh
Journal:  Aging (Albany NY)       Date:  2009-02-05       Impact factor: 5.682

6.  Effect of a recD mutation on DNA damage resistance and transformation in Deinococcus radiodurans.

Authors:  Matthew D Servinsky; Douglas A Julin
Journal:  J Bacteriol       Date:  2007-05-11       Impact factor: 3.490

7.  BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.

Authors:  Adele Adamo; Paolo Montemauri; Nicola Silva; Jordan D Ward; Simon J Boulton; Adriana La Volpe
Journal:  EMBO Rep       Date:  2008-01-25       Impact factor: 8.807

8.  Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.

Authors:  Stéphane Coulon; Eishi Noguchi; Chiaki Noguchi; Li-Lin Du; Toru M Nakamura; Paul Russell
Journal:  Mol Biol Cell       Date:  2006-02-08       Impact factor: 4.138

9.  Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycle.

Authors:  Yaron Dayani; Giora Simchen; Michael Lichten
Journal:  PLoS Genet       Date:  2011-05-26       Impact factor: 5.917

10.  Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.

Authors:  Lea Jessop; Beth Rockmill; G Shirleen Roeder; Michael Lichten
Journal:  PLoS Genet       Date:  2006-08-02       Impact factor: 5.917
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