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Literature DB >> 15506924

HMGN proteins play roles in DNA repair and gene expression in mammalian cells.

Abstract

HMGN (high-mobility-group N) family members are vertebrate proteins that unfold chromatin and promote transcription and replication of chromatin templates in vitro. However, their precise roles in vivo have been elusive until recently. This paper summarizes recent advances from studies of Hmgn1 knockout mice and genetically engineered cell lines that are beginning to reveal the diverse roles that HMGN proteins play in DNA repair and transcription within mammalian cells.

Entities: Gene Species

Mesh：

Substances：
HMGN Proteins

Year: 2004 PMID： 15506924 DOI： 10.1042/BST0320918

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

10 in total

1. Transcription regulation by the noncoding RNA SRG1 requires Spt2-dependent chromatin deposition in the wake of RNA polymerase II.

Authors: Philippe Thebault; Geneviève Boutin; Wajid Bhat; Anne Rufiange; Joseph Martens; Amine Nourani
Journal: Mol Cell Biol Date: 2011-01-10 Impact factor: 4.272

2. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.

Authors: Aya Masaoka; Natalie R Gassman; Padmini S Kedar; Rajendra Prasad; Esther W Hou; Julie K Horton; Michael Bustin; Samuel H Wilson
Journal: J Biol Chem Date: 2012-06-26 Impact factor: 5.157

3. Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.

Authors: Yu Gan; Jing Tan; Jianfu Yang; Yihong Zhou; Yingbo Dai; Leye He; Kun Yao; Yuxin Tang
Journal: Med Oncol Date: 2015-03-22 Impact factor: 3.064

4. Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.

Authors: Amine Nourani; Francois Robert; Fred Winston
Journal: Mol Cell Biol Date: 2006-02 Impact factor: 4.272

10. A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions.

Authors: Umashankar Singh; Erik Bongcam-Rudloff; Bengt Westermark
Journal: PLoS One Date: 2009-04-01 Impact factor: 3.240

10 in total

HMGN proteins play roles in DNA repair and gene expression in mammalian cells.

1. Transcription regulation by the noncoding RNA SRG1 requires Spt2-dependent chromatin deposition in the wake of RNA polymerase II.

2. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.

3. Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.

4. Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.

Review 5. Transcriptional regulation by HMGN proteins.

Review 6. Nuclear functions of the HMG proteins.

7. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.

Review 8. Biological Functions of HMGN Chromosomal Proteins.

9. Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.

10. A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions.