Literature DB >> 15506921

Zebularine: a new drug for epigenetic therapy.

C B Yoo1, J C Cheng, P A Jones.   

Abstract

Regulatory genes are often hypermethylated at their promoter 5' regions and silenced in cancer. Epigenetic therapy with DNA methylation inhibitors have been shown to result in the demethylation and reactivation of these genes. Zebularine is a recently discovered mechanism-based inhibitor of DNA methylation, and has received much attention for its potential in clinical use. Further studies exploring the effectiveness of zebularine in a variety of settings could allow the development of novel therapies for cancer.

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Year:  2004        PMID： 15506921     DOI： 10.1042/BST0320910

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  56 in total

1.  The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

Authors:  M V Simonini; L M Camargo; E Dong; E Maloku; M Veldic; E Costa; A Guidotti
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

Review 2.  A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns.

Authors:  Matthew J Provenzano; Frederick E Domann
Journal:  Hear Res       Date:  2007-07-19       Impact factor: 3.208

Review 3.  Histone modifications, DNA methylation, and schizophrenia.

Authors:  David P Gavin; Rajiv P Sharma
Journal:  Neurosci Biobehav Rev       Date:  2009-10-30       Impact factor: 8.989

4.  Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells.

Authors:  Eva Majerová; Miloslava Fojtová; Iva Mozgová; Miroslava Bittová; Jiří Fajkus
Journal:  Plant Mol Biol       Date:  2011-08-25       Impact factor: 4.076

5.  Epigenetic mechanisms in the pathophysiology of psychotic disorders.

Authors:  W Brad Ruzicka
Journal:  Harv Rev Psychiatry       Date:  2015 May-Jun       Impact factor: 3.732

6.  2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential.

Authors:  Marika Matoušová; Ivan Votruba; Miroslav Otmar; Eva Tloušťová; Jana Günterová; Helena Mertlíková-Kaiserová
Journal:  Epigenetics       Date:  2011-06-01       Impact factor: 4.528

7.  Acetoxy Meldrum's acid: a versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation.

Authors:  Barry M Trost; Maksim Osipov; Philip S J Kaib; Mark T Sorum
Journal:  Org Lett       Date:  2011-05-26       Impact factor: 6.005

8.  Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

Authors:  Stefan Kubicek; Joshua C Gilbert; Dina Fomina-Yadlin; Alexander D Gitlin; Yuan Yuan; Florence F Wagner; Edward B Holson; Tuoping Luo; Timothy A Lewis; Bradley Taylor; Supriya Gupta; Alykhan F Shamji; Bridget K Wagner; Paul A Clemons; Stuart L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-20       Impact factor: 11.205

9.  Demethylating drugs as novel analgesics for cancer pain.

Authors:  Chi T Viet; Dongmin Dang; Yi Ye; Kentaro Ono; Ronald R Campbell; Brian L Schmidt
Journal:  Clin Cancer Res       Date:  2014-06-24       Impact factor: 12.531

10.  Effective, homogeneous and transient interference with cytosine methylation in plant genomic DNA by zebularine.

Authors:  Tuncay Baubec; Ales Pecinka; Wilfried Rozhon; Ortrun Mittelsten Scheid
Journal:  Plant J       Date:  2008-10-30       Impact factor: 6.417
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