| Literature DB >> 15506732 |
Douglass F Taber1, Yigang He, Ming Xu.
Abstract
Allylic and benzylic Grignard reagents smoothly open phenylalkynyl-activated cyclic trisubstituted epoxides at the more substituted carbon atom to give secondary alcohols with a chiral quaternary center. These alcohols are good substrates for the construction of enantiomerically pure carbobicyclic scaffolds through intramolecular alkylation.Entities:
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Year: 2004 PMID： 15506732 DOI： 10.1021/ja045849k
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419