Renato S Procianoy1, Rita C Silveira. 1. Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. renatosp@terra.com.br
Abstract
OBJECTIVE: To assess different perinatal findings and sample collection timing in newborns with early-onset sepsis comparing those with low IL-6 levels to the ones with high levels. METHODS: Eighty-five newborn infants, with clinical signs of sepsis and/or positive blood cultures, had plasma IL-6 collected in the initial evaluation for early-onset sepsis in the first 96 hours of life. They were classified in two groups according to their plasma IL-6 levels: higher, and equal to or lower than IL-6 median value for the whole septic group. RESULTS: Median IL-6 for the whole group was 89 pg/ml. High and low level groups were formed by 42 and 43 newborns respectively. There were no differences between the two groups regarding gestational ages, birth weights, cesarean-section proportion, Apgar scores, number of neonates with maternal risk factors for infection, number of maternal intrapartum antibiotic therapy, and number of positive blood cultures. Median plasma IL-6 in the high level group was 287 pg/ml, and in the low level group 46 pg/ml (p < 0.001). Median sample timing was 17.5 hours of life for the high level group and 36 hours of life for the low level group (p < 0.001). There was a significant negative correlation coefficient between IL-6 levels and sample collection timing. CONCLUSION: Sample collection timing is an important factor for detection of high plasma IL-6 level in newborn infants with early-onset sepsis.
OBJECTIVE: To assess different perinatal findings and sample collection timing in newborns with early-onset sepsis comparing those with low IL-6 levels to the ones with high levels. METHODS: Eighty-five newborn infants, with clinical signs of sepsis and/or positive blood cultures, had plasma IL-6 collected in the initial evaluation for early-onset sepsis in the first 96 hours of life. They were classified in two groups according to their plasma IL-6 levels: higher, and equal to or lower than IL-6 median value for the whole septic group. RESULTS: Median IL-6 for the whole group was 89 pg/ml. High and low level groups were formed by 42 and 43 newborns respectively. There were no differences between the two groups regarding gestational ages, birth weights, cesarean-section proportion, Apgar scores, number of neonates with maternal risk factors for infection, number of maternal intrapartum antibiotic therapy, and number of positive blood cultures. Median plasma IL-6 in the high level group was 287 pg/ml, and in the low level group 46 pg/ml (p < 0.001). Median sample timing was 17.5 hours of life for the high level group and 36 hours of life for the low level group (p < 0.001). There was a significant negative correlation coefficient between IL-6 levels and sample collection timing. CONCLUSION: Sample collection timing is an important factor for detection of high plasma IL-6 level in newborn infants with early-onset sepsis.
Authors: Juliana Reis Machado; Danilo Figueiredo Soave; Marcos Vinícius da Silva; Liliana Borges de Menezes; Renata Margarida Etchebehere; Maria Luiza Gonçalves dos Reis Monteiro; Marlene Antônia dos Reis; Rosana Rosa Miranda Corrêa; Mara Rúbia Nunes Celes Journal: Mediators Inflamm Date: 2014-12-30 Impact factor: 4.711
Authors: Jordan K Vance; Travis W Rawson; Brittany G Seman; Michelle R Witt; Annalisa B Huckaby; Jessica M Povroznik; Shelby D Bradford; Mariette Barbier; Cory M Robinson Journal: Infect Immun Date: 2020-02-20 Impact factor: 3.441