Mutual assistance of hydrogen-bond pairing and aromatic stacking interactions for molecular recognition: spectroscopic study on the interaction of guanine base with cytosine and tryptophan molecules.

Fluorescence and 1H-NMR spectroscopic experiments on the interaction of guanine base with cytosine base and Trp indole ring using the model compounds have shown the first clear-cut evidence that both of the hydrogen-bond pairing and aromatic stacking interactions, which are recognized as important forces for the strict molecular recognition, do not function independently, but highly help each other for the recognition of guest molecule.