Literature DB >> 1550560

Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb/C 3T3 cells.

S T Chiou1, W C Chang.   

Abstract

Treatment of quiescent Balb/c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.

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Year:  1992        PMID： 1550560     DOI： 10.1016/0006-291x(92)90513-k

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Identification of the novel player deltaEF1 in estrogen transcriptional cascades.

Authors:  E M Chamberlain; M M Sanders
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

2.  The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.

Authors:  Minjing Li; Yancun Yin; Hui Hua; Xiangming Sun; Ting Luo; Jiao Wang; Yangfu Jiang
Journal:  J Biol Chem       Date:  2010-07-29       Impact factor: 5.157

3.  Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells.

Authors:  F Rininsland; T R Johnson; C L Chernicky; E Schulze; P Burfeind; J Ilan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-27       Impact factor: 11.205
  3 in total

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