OBJECTIVE: To investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs). METHODS: Two hundred forty-three consecutive patients with clinical manifestations of atherosclerotic disease underwent MRI of the brain and MR angiography of the circle of Willis. RESULTS: Subjects with a fetal configuration of the circle of Willis demonstrated a decreased load of small (p < 0.01) and medium (p < 0.01) deep WMLs compared with subjects with a nonfetal configuration of the posterior part of the circle of Willis. CONCLUSION: A fetal configuration of the posterior part of the circle of Willis may be an important protecting determinant in the etiology of white matter lesions.
OBJECTIVE: To investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs). METHODS: Two hundred forty-three consecutive patients with clinical manifestations of atherosclerotic disease underwent MRI of the brain and MR angiography of the circle of Willis. RESULTS: Subjects with a fetal configuration of the circle of Willis demonstrated a decreased load of small (p < 0.01) and medium (p < 0.01) deep WMLs compared with subjects with a nonfetal configuration of the posterior part of the circle of Willis. CONCLUSION: A fetal configuration of the posterior part of the circle of Willis may be an important protecting determinant in the etiology of white matter lesions.
Authors: Mangmang Xu; Wen Guo; Lucie Rascle; Laura Mechtouff; Norbert Nighoghossian; Omer Eker; Lu Wang; Nils Henninger; Abdul Ghani Mikati; Shihong Zhang; Bo Wu; Ming Liu Journal: Front Neurol Date: 2022-06-24 Impact factor: 4.086
Authors: Aaron Proweller; Alex C Wright; Debra Horng; Lan Cheng; Min Min Lu; John J Lepore; Warren S Pear; Michael S Parmacek Journal: Proc Natl Acad Sci U S A Date: 2007-10-01 Impact factor: 11.205
Authors: Mandy M A Conijn; Jeroen Hendrikse; Jaco J M Zwanenburg; Taro Takahara; Mirjam I Geerlings; Willem P Th M Mali; Peter R Luijten Journal: Eur Radiol Date: 2009-12 Impact factor: 5.315
Authors: Brett Cucchiara; Ronald L Wolf; Lidia Nagae; Quan Zhang; Scott Kasner; Ritobrato Datta; Geoffrey K Aguirre; John A Detre Journal: PLoS One Date: 2013-07-26 Impact factor: 3.240