Literature DB >> 15504890

Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamases.

Karen E Bowker1, Alan R Noel, Timothy R Walsh, Chris A Rogers, Alasdair P MacGowan.   

Abstract

A strain of Escherichia coli containing TEM-1 and CTX-M-1 was tested in an in vitro pharmacokinetic model against ceftazidime with and without AM-112, a serine beta-lactamase inhibitor. Ceftazidime alone was less effective than ceftazidime plus AM-112, and a single dose was more effective than three fractionated doses.

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Year:  2004        PMID： 15504890      PMCID： PMC525393          DOI： 10.1128/AAC.48.11.4482-4484.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Activity of moxifloxacin, administered once a day, against Streptococcus pneumoniae in an in vitro pharmacodynamic model of infection.

Authors:  A P MacGowan; K E Bowker; M Wootton; H A Holt
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Determination of minimum inhibitory concentrations.

Authors:  J M Andrews
Journal:  J Antimicrob Chemother       Date:  2001-07       Impact factor: 5.790

3.  In vitro and in vivo activities of AM-112, a novel oxapenem.

Authors:  Conor E Jamieson; Peter A Lambert; Iain N Simpson
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

4.  In-vitro pharmacodynamic simulation of clavulanic acid concentrations: effect on Staphylococcus aureus and Haemophilus influenzae beta-lactamase activity.

Authors:  M Martín; L Aguilar; I P Balcabao; M L Gómez-Lus; R Dal-Ré; J Prieto
Journal:  J Antimicrob Chemother       Date:  1997-02       Impact factor: 5.790

5.  Pharmacodynamics of piperacillin alone and in combination with tazobactam against piperacillin-resistant and -susceptible organisms in an in vitro model of infection.

Authors:  A H Strayer; D H Gilbert; P Pivarnik; A A Medeiros; S H Zinner; M N Dudley
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

6.  Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysis.

Authors:  Alan M Simm; Catherine S Higgins; Anne L Carenbauer; Michael W Crowder; John H Bateson; Peter M Bennett; Anthony R Clarke; Stephen E Halford; Timothy R Walsh
Journal:  J Biol Chem       Date:  2002-04-08       Impact factor: 5.157

7.  In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms.

Authors:  Conor E Jamieson; Peter A Lambert; Iain N Simpson
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191
  7 in total
  1 in total

Review 1.  Current challenges in antimicrobial chemotherapy: focus on ß-lactamase inhibition.

Authors:  Carine Bebrone; Patricia Lassaux; Lionel Vercheval; Jean-Sébastien Sohier; Adrien Jehaes; Eric Sauvage; Moreno Galleni
Journal:  Drugs       Date:  2010-04-16       Impact factor: 9.546
  1 in total

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