| Literature DB >> 15504437 |
Abiy Yenesew1, Martha Induli, Solomon Derese, Jacob O Midiwo, Matthias Heydenreich, Martin G Peter, Hoseah Akala, Julia Wangui, Pamela Liyala, Norman C Waters.
Abstract
The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 7.9+/-1.1 and 5.3+/-0.7 microg/ml, respectively. From this extract, a new chalcone, 2',3,4,4'-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.Entities:
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Year: 2004 PMID： 15504437 DOI： 10.1016/j.phytochem.2004.08.050
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072