Literature DB >> 1550342

Quantification of cytochrome P450 reductase gene expression in human tissues.

E A Shephard1, C N Palmer, H J Segall, I R Phillips.   

Abstract

We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little inter-individual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.

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Year:  1992        PMID： 1550342     DOI： 10.1016/0003-9861(92)90152-m

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  10 in total

1.  Regulation of NADPH-cytochrome P450 reductase expressed during Douglas-fir germination and seedling development.

Authors:  T J Tranbarger; B S Forward; S Misra
Journal:  Plant Mol Biol       Date:  2000-09       Impact factor: 4.076

2.  Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

Authors:  Udaya DeSilva; Laura Elnitski; Jacquelyn R Idol; Johannah L Doyle; Weiniu Gan; James W Thomas; Scott Schwartz; Nicole L Dietrich; Stephen M Beckstrom-Sternberg; Jennifer C McDowell; Robert W Blakesley; Gerard G Bouffard; Pamela J Thomas; Jeffrey W Touchman; Webb Miller; Eric D Green
Journal:  Genome Res       Date:  2002-01       Impact factor: 9.043

3.  Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.

Authors:  Diane Ramsden; Donald J Tweedie; Tom S Chan; Timothy S Tracy
Journal:  Drug Metab Dispos       Date:  2014-08-25       Impact factor: 3.922

4.  Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase.

Authors:  Liang Ding; Lei Li; Senyan Liu; Xiaochen Bao; Kathleen G Dickman; Stewart S Sell; Changlin Mei; Qing-Yu Zhang; Jun Gu; Xinxin Ding
Journal:  Toxicol Sci       Date:  2020-02-01       Impact factor: 4.849

5.  Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.

Authors:  G C Smith; D G Tew; C R Wolf
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

Review 6.  Structure-function relations for ferredoxin reductase.

Authors:  P A Karplus; C M Bruns
Journal:  J Bioenerg Biomembr       Date:  1994-02       Impact factor: 2.945

7.  Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.

Authors:  Hyun-Hee Jang; Arvind P Jamakhandi; Shane Z Sullivan; Chul-Ho Yun; Paul F Hollenberg; Grover P Miller
Journal:  Biochim Biophys Acta       Date:  2010-02-10

8.  Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.

Authors:  Lu Gan; Lisa L von Moltke; Lauren A Trepanier; Jerold S Harmatz; David J Greenblatt; Michael H Court
Journal:  Drug Metab Dispos       Date:  2008-10-06       Impact factor: 3.922

9.  Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.

Authors:  A V Patterson; M P Saunders; E C Chinje; D C Talbot; A L Harris; I J Strafford
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

10.  Regulatory network of mitomycin C action in human colon cancer cells.

Authors:  K Suzuki; W Yamamoto; J S Park; H Hanaoka; R Okamoto; Y Kirihara; T Yorishima; T Okamura; T Kumazaki; M Nishiyama
Journal:  Jpn J Cancer Res       Date:  1999-05
  10 in total

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