Literature DB >> 15503356

Tucumanin, a beta-hydroxy-gamma-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I.

Isabel Barrachina1, Adriana Neske, Susana Granell, Almudena Bermejo, Nadia Chahboune, Noureddine El Aouad, Olga Alvarez, Alicia Bardon, M Carmen Zafra-Polo.   

Abstract

A new beta-hydroxy-gamma-methyl-gamma-lactone bistetrahydrofuranic acetogenin, tucumanin, with the infrequent symmetrical threo/trans/threo/trans/threo relative configuration at the tetrahydrofuran rings was isolated from Annona cherimolia (Annonaceae) seeds. The inhibitory potency on the mitochondrial complex I of acetogenins with this relative configuration (tucumanin and asimicin)was compared with that shown by the corresponding pairs with an asymmetrical threo/trans/threo/trans/erythro relative configuration (laherradurin/rolliniastatin-2, and itrabin/molvizarin). All these compounds act as selective inhibitors of mitochondrial complex I in the 0.18 - 1.55 nM range.

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Year:  2004        PMID： 15503356     DOI： 10.1055/s-2004-827237

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  4 in total

1.  Antiprotozoal Constituents from Annona cherimola Miller, a Plant Used in Mexican Traditional Medicine for the Treatment of Diarrhea and Dysentery.

Authors:  Fernando Calzada; Jose Correa-Basurto; Elizabeth Barbosa; David Mendez-Luna; Lilian Yepez-Mulia
Journal:  Pharmacogn Mag       Date:  2017 Jan-Mar       Impact factor: 1.085

2.  Antihyperglycemic Activity of the Leaves from Annona cherimola Miller and Rutin on Alloxan-induced Diabetic Rats.

Authors:  Fernando Calzada; Jesús Iván Solares-Pascasio; R M Ordoñez-Razo; Claudia Velazquez; Elizabeth Barbosa; Normand García-Hernández; David Mendez-Luna; José Correa-Basurto
Journal:  Pharmacognosy Res       Date:  2017 Jan-Mar

Review 3.  An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

Authors:  Alexandra G Durán; M Teresa Gutiérrez; Francisco J R Mejías; José M G Molinillo; Francisco A Macías
Journal:  Molecules       Date:  2021-05-14       Impact factor: 4.411

4.  Experimental isolation and spectroscopic characterization of squamocin acetogenin combining FT-IR, FT-Raman and UV-Vis spectra with DFT calculations.

Authors:  José Ruiz Hidalgo; Adriana Neske; Maximiliano A Iramain; Patricia E Alvarez; Patricio Leyton Bongiorno; Silvia Antonia Brandán
Journal:  J Mol Struct       Date:  2020-06-08       Impact factor: 3.196
  4 in total

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